CD4+ T-lymphoctye proteases and genes encoding said proteases

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

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4352542, 536 232, C12N 1557, C12N 1574, C12N 1581

Patent

active

056911831

ABSTRACT:
The present invention includes the identification and isolation of a nucleic acid molecule encoding a dibasic amino acid processing endoprotease from CD4+ T-lymphocytes as well as a protein encoded by that nucleic acid molecule. The present invention also includes related nucleic acid molecules and proteins encoded by such nucleic acid molecules as well as recombinant molecules and recombinant cells that include nucleic acid molecules of the present invention. The present invention also includes use of such nucleic acid molecules and proteins to develop therapeutic compositions that enhance or inhibit dibasic amino acid processing endoprotease activity.

REFERENCES:
patent: 4929553 (1990-05-01), Bussey et al.
patent: 5077204 (1991-12-01), Brake et al.
patent: 5162220 (1992-11-01), Oshima et al.
patent: 5225537 (1993-07-01), Foster
patent: 5234830 (1993-08-01), Oshima et al.
Angliker, "The Synthesis of Inhibitors For Processing Proteinases and Their Action on the Kex2 Proteinase of Yeast", pp. 75-81, 1993, Biochem. J., vol. 293, Part 1.
Barr, "Mammalian Subtilisins: The Long-Sought Dibasic Processing Endoproteases"; pp. 1-3, 1991, Cell, vol. 66, Jul.
Hakes et al., "Isolation of Two Complementary Deoxyribonucleic Acid Clones from a Rat Insulinoma Cell Line Based on Similarities to Kex2 and Furin Sequences and the Specific Localization of Each Transcript to Endocrine and Neuroendocrine Tissues in Rats", pp. 3053-3063, 1991, Endocrinology, vol. 129, No. 6.
Kiefer et al., "Identification of a Second Human Subtilisin-Like Protease Gene in the fes/fps Region of Chromosome 15", pp. 757-769, 1991, DNA and Cell Biol., vol. 10, No. 10.
Lusson et al., "cDNA Structure of the Mouse and Rat Subtilisin/kexin-Like PC5: A Candidate Proprotein Convertase Expressed in Endocrine and Nonendocrine Cells", pp. 6691-6695, 1993, Proc. Natl. Acad. Sci. USA, vol. 90, Jul.
Moulard et al., 1993, In Int. Conf. AIDS, vol. 9(1):155 (abstract No. PO-A08-0123).
Steiner et al., pp. 23435-23438, 1992, J. Biol. Chem., vol. 267, No. 33.

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