CD4 peptides for binding to viral envelope proteins

Details CD4 peptides for binding to viral envelope proteins CD4 peptides for binding to viral envelope proteins

1993-08-31

1997-02-18

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

530328, 530329, 530330, 530402, 514 15, 514 16, 514 17, 514 18, 435 5, A61K 3900, A61K 3807, A61K 3808, C07K 511, C07K 1700

Patent

active

056039336

ABSTRACT:
Disclosed are compositions and methods for use in viral binding and inactivation and in protecting cells from viral infection, particularly, for use in protecting target human CD4.sup.+ cells from infection by HIV. Peptides including short sequences from CD4 are identified as being particularly effective at binding to gp120 and inhibiting or reducing HIV infection of human CD4.sup.+ cells by steric hinderance or catalytic inactivation of gp120. The invention thus encompasses improved CD4-based peptide compositions and therapeutic formulations with viral binding and HIV-inhibitory activity.

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