CD4 adheson variants

Details CD4 adheson variants CD4 adheson variants

1992-08-26

1994-08-09

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352573, 4353301, 536350, 5363873, 536 234, 4241341, C07K 1300, C12N 1562

Patent

active

053366034

ABSTRACT:
Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics.

REFERENCES:
patent: 3959080 (1976-05-01), Orth et al.
patent: 4002531 (1977-01-01), Royer
patent: 4055635 (1977-10-01), Green et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4444878 (1984-04-01), Paulus
patent: 4745055 (1988-05-01), Schenk et al.
patent: 4761371 (1988-08-01), Bell et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4879211 (1989-11-01), Wang et al.
Chaudhary et al., Proc. natl. Acad. Sci. U.S.A. 84: 4538-4542 (1987).
Murre et al., Mol. Cell. Biol. 6: 1315-1319 (1986).
Oi, V. T., BioTechniques 4: 214 (1986).
Peterson, A. S., Ph.D., Thesis, Harvard Univ. Chapter 1 (1988).
McDougal, et al., Molecular Biology of Homosapiens, Cold Spring harbor, N.Y. Jun. 1986.
Springer et al., Proc. Natl. Acad. Sci. U.S.A. 73(7): 2481-2485 (1976).
Seed, Nature 329:840-842 (Oct. 1987).
Goverman et al. J. Cell. Biochem. Suppl. (11 Part D) 1987, AB 334, p. 259.
Johnson et al., J. Cell. Biochem. Suppl. (11 Part D) 1987 AB 337, p. 260.
Salzawa et al., J. Cell. Biochem. Suppl. (11 Part D) 1987, AB 421, p. 273.
Hashimoto et al., J. Cell. Biochem. Suppl. (11 Part D) 1987 AB 434, p. 278.
Ivars et al., J. Cell. Biochem. Suppl. (11 Part D) 1987, AB 435, p. 278.
Sleckman et al., Nature 328:351 (Jul. 1987).
Gascoigne et al. PNAS U.S.A. 84:2936-2940 (1987).
Anderson et al. Immunology Today 9(7&8):199-203 (1988).
Littman, Ann. Rev. Immunol. 5:561-584 (1987).
Estess et al., J. Cell. Biochem. Suppl. (11 Part D) 1987, AB. 331, p. 258.
Gascoigne et al., J. Cell Biochem. Suppl. (11 Part D) 1987, AB.333, p. 259.
Littman et al., Cell 40:237-246 (1985).
Beauchamp et al., Analytical Biochem. 131:25-33 (1983).
Terhorst et al., Science 209:520-521 (1980).
McDougal et al., Science 231:382-385 (1986).
Maddon et al., Cell 47:333-348 (1986).
Morrison, S. L. Science 229:1202-1207 (1985).
Wills et al., J. Cell Biol. 99:2011-2023 (1984).
Rose et al., Cell 30:753-762 (1982).
Traunecker et al., Nature 331:84-86 (1988).
Traunecker et al., Nature 339:68-70 (1989).
Maddon et al., P.N.A.S. U.S.A. 84:9155-9159 (Dec. 1987).
Morrison et al., P.N.A.S. U.S.A. 81:6851-6855 (1984).
Morrison, S. L. J. Immunol. 123(2):793-800 (1979).
Neuberger et al., Nature 312:604-608 (1984).
Vitetta et al., Science 238:1098-1104 (1987).
Falkner et al., Nature 298:286-288 (1982).
Kohler, G. P.N.A.S. U.S.A. 77(4):2197-2199 (1980).
Maddon et al., Cell 42(1): 93-104 (1985).
Clark et al., P.N.A.S. U.S.A. 84:1649-1653 (1987).
Smith et al., Science 238:1704-1707 (1987).
Morrison et al., Paul et al., Ed., Ann. Rev. Immunol. 2:239-256 (1984).
Sharon et al., Nature 309:364-367 (1984).
Boulianne et al., Nature 312:643-646 (1984).
Rosenblum Michael G. et al., Cancer Research 45:2421-2424 (Jun. 1985).
Osborn, Laurelee et al., Cell 59:1203-1211 (Dec. 1989).

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