Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-04-26
2010-11-30
Helms, Larry R (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C436S063000, C436S064000
Reexamination Certificate
active
07842461
ABSTRACT:
The subject invention discloses a method for determining the prognosis and probable clinical course of a subject diagnosed with B-CLL. Specifically, the invention involves comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein an elevated level of CD38 expression in relation to the baseline level of CD38 expression may indicate poor prognosis or aggressive course of disease in the subject. Also disclosed is a method for determining whether the Ig V genes of the B-CLL cells of a B-CLL patient are mutated, comprising comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein a lower level of CD38 expression in relation to the baseline level indicates IG V gene mutation.
REFERENCES:
Damle, R.N., et al. Blood, 94(6): 1840-1847, 1999; September.
Hamblin, T.J. et al. Blood, 94(6): 1848-1854, 1999; September.
David, M.P.C., et al. Molecular Immunology, 44: 1342-1351, 2007.
Fais, F., et al. J. Clin. Invest, 102: 1515-1525, 1998).
Chiorazzi Nicholas
Damle Rajendra N.
Wasil Tarun
Amster Rothstein & Ebenstein LLP
Helms Larry R
Holleran Anne L
The Feinstein Institute for Medical Research
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