CD34+ peripheral blood progenitor cells obtained by ex vivo expa

Details CD34+ peripheral blood progenitor cells obtained by ex vivo expa CD34+ peripheral blood progenitor cells obtained by ex vivo expa

1995-06-06

1996-07-30

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

43524025, 424 851, 424 9371, C12N 506, C12N 502

Patent

active

055411037

ABSTRACT:
Patients suffering from certain types of cancer are treated by high-dose chemotherapy. In order to allow a recovery a process for the ex vivo expansion of peripheral blood progenitor cells is described, wherein CD 34.sup.+ -cells are enriched and cultivated in a medium comprising IL-1, IL-3, IL-6, EPO and SCF. The ex vivo expanded peripheral blood progenitor cells can be administered to cancer patients after chemotherapy.

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To et al., Exp. Hematol., 20(6):756, Abst. No. 185 (1992).
Williams et al., Blood, 79:58-64 (1992).

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