Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to lymphokine – cytokine – or other secreted growth...
Patent
1995-12-20
1998-05-19
Spector, Lorraine M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to lymphokine, cytokine, or other secreted growth...
424 169, 4241921, 4241931, 514883, 435 695, 435 697, 530351, 530402, A61K 5108, C07K 1452
Patent
active
057532036
ABSTRACT:
There is disclosed a polypeptide (CD30-L) and DNA sequences, vectors and transformed host cells useful in providing CD30-L polypeptides. The CD30-L polypeptide binds to the receptor known as CD30, which is expressed on a number of cell types, among which are Hodgkin's Disease tumor cells, large cell anaplastic lymphoma cells, adult T-cell leukemia (T-ALL) cells, and a number of other malignant cell types. CD30-L polypeptides and oligomers find use as carriers for delivering diagnostic and cytotoxic agents to cells expressing the CD30 receptor.
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Armitage Richard J.
Goodwin Raymond G.
Gruss Hans-Juergen
Smith Craig A.
Anderson Kathryn A.
Immunex Corporation
Spector Lorraine M.
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