Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-09-03
1999-07-27
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038875, 536 2353, 435 7021, 435271, C07K 1900, C07H 2104
Patent
active
059292121
ABSTRACT:
The invention provides recombinant antibody molecules comprising antigen binding regions derived from the heavy and/or light chain variable regions of a donor anti-CD3 antibody, e.g. OKT3, and which have anti-CD3 binding specificity, preferably of affinity similar to that of OKT3. The recombinant antibody is preferably a humanized antibody and may be a chimeric or CDR-grafted antibody. A method is disclosed for preparing CDR-grafted humanized antibodies in which, in addition to the CDR's, non-human antibody residues are preferably used at positions 23, 24, 49, 71, 73 and 78 of the heavy chain variable region and at positions 46, 48, 58, and 71 of the light chain variable region. The recombinant, especially the humanized, anti-CD3 antibodies may used for in vivo therapy or diagnosis.
REFERENCES:
patent: 5530101 (1996-06-01), Queen et al.
patent: 5535089 (1996-07-01), Queen et al.
Riechmann, et al. Nature 332:323-327 1988.
Queen, et al PNAS 86:10029-10033 1989.
Smith, et al Nature 337: 181-184 1989.
Jaffers, et al Transplantation 43(6) 572-578 1986.
Roberts et al, "Generation of Antibody with Enhanced Affinity and Specificity for its Antigen by Protein Engineering" Nature, 328(20):731-734, Aug., 1987.
Verhoeyen et al, "Reshaping Human Antibodies: Grafting an Antilysozyme Activity", Science, 239:1534-36 Mar. 25, 1988.
Levitt, et al., JMP, (1983) 168:595-620.
Waldmann, Science 252:1657-1662 (1991).
Harris et al., Tibtech 11:42-46 (1993).
Osband et al., Immunotherapy 11(6):193-195 (1990).
Dillman, Ann. Internal Med. 111:592-603 (1989).
Hird et al., Genes and Cancer (1990) chapter 17.
Cunningham et al., Tibtech 10: (1992).
Kettleborough et al., Protein Engineering $(7):773-783 (1991).
Adair John Robert
Athwal Diljeet Singh
Jolliffe Linda Kay
Zivin Robert Allan
Celltech Therapeutics Limited
Eisenschenk Frank C.
Nolan Patrick
LandOfFree
CD3 specific recombinant antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with CD3 specific recombinant antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and CD3 specific recombinant antibody will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-879852