Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-03-29
1996-05-28
Adams, Donald E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
435 691, 435 697, 435 911, 4352523, 43525233, 4353201, 4352401, 435 72, 435 792, 530300, 530350, 5303871, 530395, 530409, 530866, 530867, 530868, 536 231, 536 234, 536 2353, C07K 1646, C07K 14725, C07K 1400, C07H 2104
Patent
active
055212883
ABSTRACT:
The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular domains of B7 or CD28 joined to amino acid sequences encoding portions of human immunoglobulin C.gamma.1, are described. Methods are provided for using B7 antigen, its fragments and derivatives, and the CD28 receptor, its fragments and derivatives, as well as antibodies and other molecules reactive with B7 antigen and/or the CD28 receptor, to regulate CD28 positive T cell responses, and immune responses mediated by T cells. The invention also includes an assay method for detecting ligands reactive with cellular receptors mediating intercellular adhesion.
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Ledbetter and Herzenberg, "X
Brady William
Damle Nitin K.
Ledbetter Jeffrey A.
Linsley Peter S.
Adams Donald E.
Bristol--Myers Squibb Company
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