CD28 mimetics for blocking T cell mediated immune reactions

Details CD28 mimetics for blocking T cell mediated immune reactions CD28 mimetics for blocking T cell mediated immune reactions

2007-05-22

2007-05-22

Gambel, Phillip (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S324000, C530S325000, C530S326000, C530S345000

Reexamination Certificate

active

09990574

ABSTRACT:
Agents for blocking T cell-mediated immune reactions are provided. Such agents are peptides, referred to as “CD28 peptide mimetics”, of from 15 to 30 amino acids in length. The CD28 peptide mimetics comprise the hexapeptide motif ‘MYPPPY’, SEQ ID NO:1,or a retro-inverso isomer thereof. The CD28 peptide mimetics further comprise flanking sequence at the amino and carboxyl terminus of the hexapeptide motif. Methods for treating subjects with T cell mediated autoimmune diseases or disorders are also provided. Such methods comprise administering one or more of the CD28 peptide mimetics to a subject with such a disease or disorder.

REFERENCES:
patent: 5773253 (1998-06-01), Linsley et al.
patent: 2002/0182727 (2002-12-01), Freeman et al.
patent: 2004/0229790 (2004-11-01), Tezuka et al.
Altwood, Science, 2000, vol. 290, pp. 471-473.
Skolnick et al., Trends in Biotech, 2000, vol. 18, pp. 34-39.
Metzler et al., Nature Structural Biol. 1997; 4:527-531.
“Costimulatory Blockade by CD28 Peptide Mimics: Suppression of Experimental Autoimmune Encephalomyelitis” by Srinivasan, et al.,American Peptide Society, Jun. 9, 2001, pp. 654-655.
“A CD28 CDR3 peptide analog inhibits CD4+ T-cell proliferationin vitro” by Srinivasan, et al.,Peptides for the New Millenium(Eds. Fields, G.B., Tam T.P. and Barany) Kluwer Academic Publishers, Dordrecht, Netherlands, Jun. 26, 1999, pp. 689-690.
“A Retro-Inverso Peptide Mimic of CD28 Encompassing the MYPPPY Motif Adopts a Polyproline Type II Helix and Inhibits Encephalitogenic T Cells In Vitro” by Srinivasan,The Journal of Immunology, vol. 167(1), Jul. 1, 2001, pp. 578-585.
“Suppression of Experimental Autoimmune Encephalomyelitis Using Peptide Mimics of CD28” by Srinivasan, et al.,Journal of Immunology, 2002, 169: 2180-2188.

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