Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-04-10
2011-12-27
Ouspenski, Ilia (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
08084217
ABSTRACT:
The invention relates to a CD161 ligand known as Proliferation-Induced Lymphocyte-Associated Receptor (PILAR), which is crucial for a robust expansion of human lymphocytes. PILAR is markedly up-regulated on both CD4 and CD8 T cells upon TCR engagement and increases the expression of anti-apoptotic genes and glucose transporters through CD161, which globally results in a dramatic enhancement of T cell proliferation. Agents which stimulate or block this activity are also provided as are methods for manipulating PILAR signaling in the treatment of disease.
REFERENCES:
Exley et al., J. Exp. Med., 1998, 188: 867-876.
NCBI entry CLC2A—HUMAN (2011), 5 pages.
Aldemir et al. “Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor” The Journal of Immunology 2005 vol. 175(2) 7791-7795.
Benencia et al. “CLEC2A2 is a Novel Regulatory Immunoreceptor” Abstract presented at New England Immunology Conference, Oct. 2006.
NCBI Accession No. EF127467 (Huarte-Sobrino et al.) Nov. 2, 2006.
NCBI Accession No. NM 207375 (Clark et al.) 2003.
NCBI Accession No. AAQ89483 (Clark, H.F.) Dec. 2003.
Conejo-Garcia Jose R.
Cubillos-Ruiz Juan
Huarte-Sobrino Eduardo
Martinez Diana G.
Nesbeth Yolanda
Licata & Tyrrell P.C.
Ouspenski Ilia
Trustees of Dartmouth College
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