Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-07-22
1993-04-27
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 697, 4351723, 4353201, 43525233, C12N 1511
Patent
active
052063534
ABSTRACT:
A chimeric gene directing the synthesis of hybrid recombinant fusion protein in a suitable expression vector has been constructed. The fusion protein possesses the property of selective cytotoxicity against specific virus-infected cells. A CD4(178)-PE40 hybrid fusion protein has been made for selectively killing HIV-infected cells.
REFERENCES:
Chaudhary, et al. Proc. Natl. Acad. Sci:USA 84:4538-4542, 1987.
McDougal, et al. Science 231:382-385, 1986.
Maddon, et al. Cell 42: 93-104, 1985.
Chakrabaty et al. Nature 320:535-537, 1986.
Berger Edward A.
Chaudhary Vijay K.
FitzGerald David
Fuerst Thomas R.
Mizukami Tamio
LeGuyader J.
Schwartz Richard A.
The United States of America as represented by the Department of
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