CD-4/cytotoxic gene fusions

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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435 697, 4351723, 4353201, 43525233, C12N 1511

Patent

active

052063534

ABSTRACT:
A chimeric gene directing the synthesis of hybrid recombinant fusion protein in a suitable expression vector has been constructed. The fusion protein possesses the property of selective cytotoxicity against specific virus-infected cells. A CD4(178)-PE40 hybrid fusion protein has been made for selectively killing HIV-infected cells.

REFERENCES:
Chaudhary, et al. Proc. Natl. Acad. Sci:USA 84:4538-4542, 1987.
McDougal, et al. Science 231:382-385, 1986.
Maddon, et al. Cell 42: 93-104, 1985.
Chakrabaty et al. Nature 320:535-537, 1986.

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