CCR9 inhibitors and methods of use thereof

Details CCR9 inhibitors and methods of use thereof CCR9 inhibitors and methods of use thereof

2007-10-16

2007-10-16

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S256000, C514S336000, C514S350000, C514S432000, C544S335000, C544S405000, C544S406000, C546S268100, C546S314000, C549S023000

Reexamination Certificate

active

11391633

ABSTRACT:
The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.

REFERENCES:
patent: 5541186 (1996-07-01), Breu et al.
patent: 5589478 (1996-12-01), Yamada et al.
patent: 6136971 (2000-10-01), Harrington et al.
patent: 6939885 (2005-09-01), Ungashe et al.
patent: 2004/0167113 (2004-08-01), Ugashe et al.
patent: 2004/0171654 (2004-09-01), Ugashe et al.
patent: 2005/0137193 (2005-06-01), Ungashe et al.
patent: WO 2004/046092 (2004-06-01), None
patent: WO 2004/085384 (2004-10-01), None
patent: WO 2005/112925 (2005-12-01), None
Silvestri et al. Medicinal Chemistry Research, 11(4): 195-218, 2002. CA 138:187588, 2002.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48: 3-26, 2001.
Kelsall et al. Immunol. Rev. 20691): 132-148, 2005.
Yu et al. J. Immunol. 164(3): 1293-1305, 2000.
Haste et al. FEBS Letters 527255-262, 2002.
Street et al. Journal of Chemical Research, Synopses, 5: 154-155, 1987. CA 108:37599,1988.
International Search Report issued in PCT Application No. PCT/US03/16090, which corresponds to U.S. Appl. No. 11/391,633.
Street, Jonathan D., et al., “Cyclizing nucleophilic addition to azinium systems. Part 2. Reactions of 3-acylpyridinium hydrazones,”Journal of Chemical Research, Synopses, vol. 5 (1987) pp. 154-155 (abstract only).
Street, Jonathan D., et al., “Cyclising Nucleophilic Addition to Azinium Systems. Part 2. Reactions of 3-Acylpyridinium Hydrazones,”Journal of Chemical Research(S) (1987) pp. 154-155.
Dannhardt, Gerd, et al., “COX-1/COX-2 inhibitors based on the methanone moiety,”European Journal of Medicinal Chemistry, vol. 37 (Feb. 2002) pp. 147-161.
Supplementary European search report issued Feb. 1, 2006 in European Application No. EP 03755422.7, which corresponds to U.S. Appl. No. 10/443,155.

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