CC-1065 analogs

Details CC-1065 analogs CC-1065 analogs

1995-06-07

1998-04-14

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548433, 548300, 548237, 548181, 544355, 544405, 546168, 546271, C07D48708

Patent

active

057393508

ABSTRACT:
This invention provides some new synthetically obtained compounds of formula I and II ##STR1## which are useful as chemical intermediates. Representative formula I or II compounds have also been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.
In addition, the compounds of formula I or II can be linked to monoclonal antibodies, either directly or via known linking group, as a means of selectively delivering the CC-1065 analogs (Compounds of Formula I and II) to those target cells expressing the target antigen and thus selectively eliminating those diseased cells from the animal or human. Further, the compounds of formula I and II can be linked to soluble human CD4 or a soluble human CD4 protein fragment capable of binding to the gp120 envelope protein of the human immuno-virus and thus eliminate virally infected cells.

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patent: 4741900 (1988-05-01), Alvarez et al.
patent: 4912227 (1990-03-01), Kelley et al.
D.G. Martin et al., Journal of Antibiotics, 38, 746-752 (1985).
W. Wierenga, J. Am. Chem. Soc., 103, No. 18, 5621-5623 (1981).
P.D. Senter et al., Proc. Natl. Acad. Sci. USA, vol. 85, 4842-46, Jul. 1988 (Immunology).
Warpehoski, M.A. et al., Stereoelectronic Factors Influencing the Biological Activity and DNA Interaction of Synthetic Antitumor Agents Modeled on CC-1065, J. Med. Chem. 31:590-603 (1988).

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