CB-1 receptor modulator formulations

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S345000, C514S277000, C514S183000, C546S300000, C546S290000, C424S486000

Reexamination Certificate

active

08003672

ABSTRACT:
Described herein are solid, stable pharmaceutical formulations of cannabinoid receptor inverse agonists, such as taranabant, and processes of making such formulations. Additionally, described herein are solid stable pharmaceutical formulations of cannabiniod inverse agonists, such as taranabant, and an additional therapeutic agent, as well as processes for making such pharmaceutical formulations.

REFERENCES:
patent: 6699871 (2004-03-01), Edmondson et al.
patent: 7326708 (2008-02-01), Cypes et al.
patent: 2005/0008706 (2005-01-01), Holm et al.
patent: 2007/0104741 (2007-05-01), Murty et al.
patent: WO03/077847 (2003-09-01), None
patent: WO03/077847 (2003-09-01), None
patent: WO2006/119260 (2006-11-01), None
patent: WO2006/119260 (2006-11-01), None
STN Registry record for taranabant (Jul. 2004).
“The mechanisms of drug release from solid dispersions in water-soluble polymers” by Craig, Int. J. Pharmaceut. 231, 131-44 (2002).
“Solid Dispersion of Poorly Water-Soluble Drugs: Early Promises, Subsequent Problems, and Recent Breakthroughs” by Serajuddin, J. Pharm. Sci. 88, 1058-66 (1999).
“Drug delivery strategies for poorly water-soluble drugs” by Fahr et al., Expert Opin. Drug Deliv. 4, 403-16 (2007).
“Improving drug solubility for oral delivery using solid dispersions” by Leuner et al., Eur. J. Pharmaceut. Biopharm. 50, 47-60 (2000).
“Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs” by Vasconcelos et al., Drug Discovery Today 12, 1068-75 (2007).

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