Caveolin peptides and their use as therapeutics

Details Caveolin peptides and their use as therapeutics Caveolin peptides and their use as therapeutics

2003-02-04

2009-02-24

Goddard, Laura B (Department: 1642)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000

Reexamination Certificate

active

07494976

ABSTRACT:
The present invention relates generally to compositions and methods useful for treating various conditions and afflictions, such as inflammation and cancer. More specifically, the present invention relates to compositions and methods of treatment which utilize peptides comprising at least one caveolin scaffolding domain. Even more specifically, the present invention relates to compositions of fusion peptides comprising the antennapedia homeodomain fused to a caveolin scaffolding domain and to methods of using these peptides to treat various conditions and afflictions.

REFERENCES:
patent: 1 076 091 (2001-02-01), None
Straub et al (1993, J Biol Chem 268(29): 21997-20003).
Kouklis et al (1993, J Cell Science, 106(pt 3): 919-28).
Bowie et al (Science, 1990, 247:1306-1310.
Michel et al (J of Biological Chemistry, 1997, 272:25907-25912, IDS).
Glenney et al (Proc Natl Acad Sci, 1992, 89:10517-10521).
Johnstone and Thorpe (Immunochemistry in Practice, 2nd Ed., 1987, Blackwell Scientific Publications, Oxford, pp. 49-50).
Derossi et al (Trends Cell Biol, 1998, 8:84-87, IDS).
Sequence search results #1-13 for UniProt database, p. 1-2.
Garcia-Cardena et al, J of Biological Chemistry, 1997, 272:25437-25440.
Tang et al, J of Biological Chemistry, 1996, 271:2255-2261.
iHOP p. 1-2.
Bowie et al (Science, 1990, 247:1306-1310).
Biederer et al (Biochemica et Biophysica Acta, 1998, 1406:5-9).
Minetti et al (Nature Genetics, 1998, 18:365-368).
Bucci et al., In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation, Nat. Med. 6:1362-1367 (2000).
Couet et al., Identification of peptide and protein ligands for the caveolin-scaffolding domain, J. Biol. Chem. 272:6525-6533 (1997).
Derossi et al., Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent, J. Biol. Chem. 271:18188-18193 (1996).
Fawell et al., Tat-mediated delivery of heterologous proteins into cells, Proc. Natl. Acad. Sci. USA 91:664-668 (1994).
Garcia-Cardena et al., Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling, Proc. Natl. Acad. Sci. USA 93:6448-6453 (1996).
Garcia-Cardena et al., Dissecting the interaction between nitric oxide synthase (NOS) and caveolin, J. Biol. Chem. 272:25437-25440 (1997).
Ghosh et al., Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase, J. Biol. Chem. 273:22267-22271 (1998).
Huang et al., Hypertension in mice lacking the gene for endothelial ntiric oxide synthase, Nature 377:239-242 (1995).
Ju et al., Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity, J. Biol. Chem. 272:18522-18525 (1997).
Kurzchalia et al., Membrane microdomains and caveolae, Curr. Opin. Cell. Biol. 11:424-431 (1999).
Lee et al., Impaired wound healing and angiogenesis in eNOS-deficient mice, Am. J. Physiol. 277:H1600-1608 (1999).
Li et al., Src tyrosine kinases, Gasubunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin, J. Biol. Chem. 271:29182-29190 (1996).
Lin et al., Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence, J. Biol. Chem. 270:14255-14258 (1995).
Liu et al., The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the golgi region of cells: a green fluorescent protein study, J. Cell. Biol. 137:1525-1535 (1997).
Michel et al., Caveolin versus calmodulin, J. Biol. Chem. 272:25907-25912 (1997).
Murohara et al., Nitric oxide synthase modulates angiogenesis in response to tissue ischemia, J. Clin. Invest. 101:2567-2578 (1998).
Nasu et al., Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells, Nat. Med. 4:1062-1064 (1998).
Oehlke et al., Cellular update of an α-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically, Biochim. Biophys. Acta 1414:127-139 (1998).
Razani et al., Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A, J. Biol. Chem. 274:26353-26360 (1999).
Rojas et al., Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor, J. Biol. Chem. 271:27456-27461 (1996).
Roy et al., Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains, Nat. Cell Biol. 1:98-105 (1999).
Rudic et al., Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling, J. Clin. Invest. 101:731-736 (1998).
Smart et al., Caveolins, liquid-ordered domains, and signal transduction, Mol. Cell. Biol. 19:7289-7304 (1999).
Sternberg et al., Caveolin, cholesterol and Ras signaling, Nat. Cell Biol. 1:E35-37 (1999).
Derossi et al. 1998, Cell Biology 8:84-87.
Guillermo et al. 1997, The Journal of Biological Chemistry 272:25437-25440.
Liu et al. 1999, The Journal of Biological Chemistry 274:15781-15785.
Mashimo et al. 1999, American Journal of Physiology 277:G745-G750.
Smart et al. 1999, Molecular and Cellular Biology 19:7289-7304.
Feron et al., 1998 Modulation of the endothelial nitric-oxide synthase-caveolin interaction in cardiac myocytes, J. Biol. Chem. 273:30249-30254.

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