Cationized carriers for immunogen production

Details Cationized carriers for immunogen production Cationized carriers for immunogen production

1990-11-21

1992-08-25

Nucker, Christine

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

530362, 530403, 530404, 530405, 530406, 530409, 424 88, C07K 1706, A61K 39385

Patent

active

051420279

ABSTRACT:
A conjugate of a protein carrier and an antigen is disclosed. The carrier protein is cationized and the conjugate has enhanced immunogenic properties over those of the antigen alone. Cationization can be accomplished by derivatization of native carboxyl groups on the protein with an aklyl diamine, e.g. ethylene diamine, resulting in the formation of side chain aminoalkylamide groups, e.g. aminoethylamide.

REFERENCES:
patent: 4384995 (1983-05-01), Stevens
patent: 4769237 (1988-09-01), Bittle et al.
Chu et al (1982) J. Immunol. Methods 55: 73-78.
Border et al (1982) J. Clin. Invest. 69:451-461.
Pescer et al (1986) J. Immunol. Methods 87:21-27.

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