Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Patent
1990-11-21
1992-08-25
Nucker, Christine
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
530362, 530403, 530404, 530405, 530406, 530409, 424 88, C07K 1706, A61K 39385
Patent
active
051420279
ABSTRACT:
A conjugate of a protein carrier and an antigen is disclosed. The carrier protein is cationized and the conjugate has enhanced immunogenic properties over those of the antigen alone. Cationization can be accomplished by derivatization of native carboxyl groups on the protein with an aklyl diamine, e.g. ethylene diamine, resulting in the formation of side chain aminoalkylamide groups, e.g. aminoethylamide.
REFERENCES:
patent: 4384995 (1983-05-01), Stevens
patent: 4769237 (1988-09-01), Bittle et al.
Chu et al (1982) J. Immunol. Methods 55: 73-78.
Border et al (1982) J. Clin. Invest. 69:451-461.
Pescer et al (1986) J. Immunol. Methods 87:21-27.
Domen Patricia L.
Hermanson Greg
Kim Kay K.
Nucker Christine
Pierce Chemical Company
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