Chemistry: analytical and immunological testing – Involving production or treatment of antibody
Patent
1987-08-17
1991-04-02
Schain, Howard E.
Chemistry: analytical and immunological testing
Involving production or treatment of antibody
424 858, 435 723, 530389, 530391, A61K 3900
Patent
active
050046977
ABSTRACT:
The rate of trancytosis of antibodies across the blood-brain barrier is increased by cationizing the antibodies to provide cationized antibodies having an isoelectric point of between about 8.0 to 11.0. The increased rates of transport across the blood-brain barrier makes such cationized antibodies useful for both neurodiagnostic and neuropharmaceutical purposes. Methods for preparing such cationized antibodies are disclosed.
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Alkermes
Koh Choon P.
Schain Howard E.
Univ. of CA
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