Cationic substituted benzofurans as antimicrobial agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S397000, C514S469000

Reexamination Certificate

active

07417158

ABSTRACT:
A method of treating aMycobacterium tuberculosisinfection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such asLeishmania donovani, Trypanosoma brucei rhodesiense, aTrypanosoma cruzi, andPlasmodium falciparum, and fungal pathogens, such asCandida albicans, Aspergillus fumigatus, andCryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.

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International Search Report corresponding to PCT app. No. PCT/US04/40557 dated Jul. 14, 2005.
Written Opinion corresponding to PCT app. No. PCT/US04/40557 dated Jul. 14, 2005.
Verner et al. “Development of serine Protease Inhibitors displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa”,J. Med. Chem., 44: 2753-2771, 2001.
International Preliminary Report on Patentability corresponding to PCT application No. PCT/US2004/040557 dated Jun. 15, 2006.
Written Opinion of the International Searching Authority corresponding to PCT application No. PCT/US04/40557 dated Jul. 14, 2005.

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