Cationic polyacrylates and poly(alkyl) acrylates or the correspo

Details Cationic polyacrylates and poly(alkyl) acrylates or the correspo Cationic polyacrylates and poly(alkyl) acrylates or the correspo

1998-04-27

1999-11-16

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4353201, 435455, 435458, 536 231, C12Q 168, C12N 1563, C07H 2104

Patent

active

059855738

ABSTRACT:
The present invention relates to a synthetic transfection or blocking system comprising as a carrier a cationic, water soluble or water dispersable polyacrylate, a polyacrylamide, a poly(C.sub.1-6 alkyl)acrylate or poly(C.sub.1-6 alkyl)acrylamide. In addition, it relates to a method for introducing DNA fragments in target cells, comprising contacting these DNA fragments with a polyacrylate, a polyacrylamide, a poly(C.sub.1-6 alkyl)acrylate or poly(C.sub.1-6 alkyl)acrylamide, which is at least partially substituted with cationic substituents and subsequently contacting the obtained transfection system with target cells. Finally, the invention involves the use of a polyacrylate, a polyacrylamide, a poly(C.sub.1-6 alkyl)acrylate or poly(C.sub.1-6 alkyl)acrylamide, which is at least partially substituted with cationic substituents as a DNA carrier system.

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