Cationic phospholipids for transfection

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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558169, A61K 9127, C07F 910

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056519818

ABSTRACT:
A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.

REFERENCES:
patent: 4480041 (1984-10-01), Myles et al.
patent: 4493832 (1985-01-01), Teraji et al.
patent: 4562179 (1985-12-01), Teraji et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 4946787 (1990-08-01), Eppstein et al.
patent: 4948576 (1990-08-01), Verdicchio et al.
patent: 5153347 (1992-10-01), Lloyd
patent: 5344930 (1994-09-01), Reiss et al.
patent: 5420330 (1995-05-01), Brush
Bruznik, K.S. et al. "A General Method for the Synthesis of Glycerophospholipids" J. Org. Chem. 1985, 51, 2368-2370 1985.
Chen, J-S et al. Chemical Abstracts, vol. 73, No. 24844; Can. J. Biochem. 1970 48(5), 585-593 1970.
Booklet from Nov. 1, 1991, Northwestern University Chemistry Department Fall Symposium, entitled "Advances in Nucleic Acids Chemistry."
List of Posters presented at Nov. 1, 1991 Northwestern University Chemistry Chemistry Department Fall Symposium.
Abstract of Poster by Gary W. Ashley, Miho Shida, and Robert MacDonald, presented at Nov. 1, 1991 Northwestern University Chemistry Department Fall Symposium.
Liposome Technology, vol. 1, Chapter 1, pp. 1-37 (G. Gregoriadis, Ed., CRC Press, 1993), Chapter 3, pp. 49-65, Chapter 27, pp. 487-499, Chapter 28, pp. 501-525.
Graham and Van der Eb, Virology 52, 456 (1973).
Kawai and Nishizawa, Mol. Cell Biol. 4, 1172 (1984).
Neumann et al., EMBO Journal 1, 841 (1982).
Graessmann and Graessman in Microinjection and Organelle Transplantation Techniques, pp. 3-13 (Cells et al., Eds., Academic Press 1986).
Cudd and Nicolau, in Liposome Technology, pp. 207-221 (G. Gregoriadis, Ed., CRC Press 1984).
Cepko et al., Cell 37, 1053 (1984).
Schaffner, Proc. Natl. Acad. Sci. USA 77, 2163 (1980).
Magee et al., Biochim. Biophys. Acta 451, 610-618 (1976).
Straub et al., Infect. Immun. 10, 783-792 (1974).
Martin and MacDonald, J. Cell Biol. 70, 515-526 (1976).
Magee et al., J. Cell. Biol. 63, 492 (1974).
Steger and Desnick, Biochim. Biophys. Acta, 464, 530 (1977).
Juliano and Stamp, Biochem. Pharma. 27, 21-27 (1978).
Mayhew et al., Cancer Res. 36, 4406 (1976).
Kimelberg, Biochim. Biophys. Acta 448, 531 (1976).
Thierry et al. in Gene Regulation: Biology of Antisense RNA and DNA, p. 147 (Erickson and Izant, Eds., Raven Press, New York, 1992).
Hug and Sleight, Biochim. Biophys. Acta 1097, 1 (1991).
Nicolau and Cudd, Crit. Rev. Ther. Drug Carr. Sys. 6, 239 (1989).
Senior et al., Biochim. Biophys. Acta 1070, 173 (1991).
Felgner et al., Proc. Natl. Acad. Sci. USA 84, 7413 (1987).
Rose et al., BioTechniques 10, 520 (1991).
Malone et al., Proc. Natl. Acad. Sci. USA 86, 6077 (1989).
Zhou and Haung, J. Controlled Release 19, 269 (1992).
Hawley-Nelson et al., Focus. 15, 73 (1990, BRL publications).
Farhood et al., Biochim. Biophys. Acta 1111, 239 (1992).
Gao and Huang, Biochim. Biophys. Res. Comm. 179, 280 (1991).
Holt et al., Neuron 4, 203 (1990).
Ono et al., Neurosci. Lett. 117, 259 (1990).
Brigham et al., Am. J. of Med. Sci. 298, 278 (1989).
Nabel et al., Science 249, 1285 (1990).
Lim et al., Circulation 83, 2007 (1991).
Hazinski, Sem. Perinatol. 16, 200 (1992).
Yosimura et al., Nucleic Acids Res. 20, 3233 (1992).
Hyde et al., Nature 362, 250 (1993).
Ballas et al., Biochim. et Biophys. Acta 939, 8 (1988).
Pinnaduwage et al., Biochim. et Biophys. Acta 985, 33 (1989).
Taylor et al., Nucleic Acids Res. 20, 4559-4565 (1992).
Leventis and Sivius, Biochim. et Biophys. Acta 1023, 124 (1990).
Duzgunes and Felgner, Methods in Enzymology 221, 303 (1993).
Smith et al., Biochim. Biophys. Acta 1154, 327 (1993).
Maccarrone et al., Biochem. Biophys. Res. Comm. 186, 1417 (1992).
Gershon et al., Biochem. 32, 7143-7151 (1993).
Legendre and Szoka, Pharm. Res. 9, 1235 (1992).
Renkonen, Biochim. et Biophys. acta 152, 114 (1968).
Gorman et al., Mol. Cell. Biol. 2, 1044 (1982).
de Wet et al., Mol. Cell. Biol. 7, 725 (1987).
Jarnagin et al., Nucl. Acids Res. 20, 4205 (1992).
Zhu et al., Science 261, 209-211 (1993).
Stribling et al., Proc. Natl. Acad. Sci. USA 89, 11277-11281 (1992).
Chen and Barton, Canadian Journal of Biochemistry 48:585-593 (1970).
Felgner, P.L. et al., Proc. Natl. Acad. Sci. USA 84:7413-7417 (1987).
Hawley-Nelson, P. et al., Focus 15:73-79 (1990).
Qiu, X. et al., J. Org. Chem. 59:537-543 (1994).
Law, S-J. et al., Tetrahedron Letters 27:271-274 (1986).
Renkonen, O., Biochim. Biophys. Acta 152:114-135 (1968).

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