Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2005-02-08
2005-02-08
Nguyen, Dave T. (Department: 1632)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C435S320100, C435S455000, C435S458000, C514S04400A
Reexamination Certificate
active
06852334
ABSTRACT:
The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth liposomes or other lipid-based formulation for enhancing cellular uptake. The CPLs of the present invention comprise a lipid moiety; a hydrophilic polymer; and a polycationic moiety. Method of increasing intracellular delivery of nucleic acids are also provided.
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Chen Tao
Cullis Pieter R.
Fenske David B.
Palmer Lorne R.
Wong Kim
Nguyen Dave T.
Oppedahl & Larson LLP
The University of British Columbia
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