Cationic oligopeptides having microbicidal activity

Details Cationic oligopeptides having microbicidal activity Cationic oligopeptides having microbicidal activity

1982-11-19

1985-09-24

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601125R, 435 68, 435 70, C07C10352, A61K 3700, C12P 2100, C12P 2102

Patent

active

045432520

ABSTRACT:
Novel microbicidal compositions are provided which find use as preservatives, disinfectants, antigens and the like. Particularly, cationic oligopeptides of up to about thirty-five amino acids are provided having amino acid sequences substantially comparable to the amino acid sequences of cationic oligopeptides produced by macrophage. A conserved framework structure is provided.

REFERENCES:
Delafeld, PhD Thesis, USC, Los Angeles, 1980, "Isolation . . . Two Microbicidal Proteins".
Zeya, H. I. et al., J. Exp. Med., vol. 127, pp. 927-941, "Arginine-Rich Proteins . . . ".
Patterson-Delafeld et al., Infec. and Immun., vol. 30(1), pp. 180-192, 1980.
Patterson-Delafeld et al., Infect. and Immun., vol. 31(2), pp. 723-731, Feb. 1981.

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