Cationic liposome delivery of taxanes to angiogenic blood...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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C514S824000

Reexamination Certificate

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07112338

ABSTRACT:
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

REFERENCES:
patent: 4394448 (1983-07-01), Szoka, Jr. et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 5092885 (1992-03-01), Yamada et al.
patent: 5110730 (1992-05-01), Edington et al.
patent: 5192744 (1993-03-01), Bouck et al.
patent: 5202352 (1993-04-01), Okada et al.
patent: 5264618 (1993-11-01), Felgner et al.
patent: 5328470 (1994-07-01), Nabel et al.
patent: 5415869 (1995-05-01), Straubinger et al.
patent: 5512294 (1996-04-01), Li et al.
patent: 5556878 (1996-09-01), Kelly et al.
patent: 5580899 (1996-12-01), Mayhew et al.
patent: 5641755 (1997-06-01), Weichselbaum
patent: 5683715 (1997-11-01), Boni et al.
patent: 5770581 (1998-06-01), Weichselbaum
patent: 5830880 (1998-11-01), Sedlacek et al.
patent: 5837283 (1998-11-01), McDonald et al.
patent: 5837682 (1998-11-01), Folkman
patent: 5885833 (1999-03-01), Mueller et al.
patent: 5935937 (1999-08-01), Smith
patent: 5965739 (1999-10-01), Kelly et al.
patent: 5977163 (1999-11-01), Li et al.
patent: 6096331 (2000-08-01), Desai et al.
patent: 6146659 (2000-11-01), Rahman
patent: 6419692 (2002-07-01), Yang et al.
patent: 0819758 (1998-01-01), None
patent: WO 91/06309 (1991-05-01), None
patent: WO 93/12240 (1993-06-01), None
patent: WO 93/12756 (1993-07-01), None
patent: WO 93/18751 (1993-09-01), None
patent: WO 93/24640 (1993-12-01), None
patent: WO 93/25673 (1993-12-01), None
patent: WO 95/29242 (1995-11-01), None
patent: WO 00/47235 (2000-08-01), None
Belotti, et al. “The microtubule-affecting drug paclitaxel has antiangiogenic activity”,Clinical Cancer Research, (1996) vol. 2: 1843-1849.
Bernsdorff, et al. “Interaction of the anticancer agent Taxol™ (paclitaxel) with phospholipid bilayers”,J. Biomed. Mater Res.,(1999) vol. 46(2): 141-149.
Brigham, et al. “Expression of a prokaryotic gene in cultured lung endothelial cells after lipofection with a plasmid vector”,Am. J. Respir. Cell Mol. Biol.,(1989) vol. 1: 95-100.
Brigham, et al. “Rapid communication: In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle”, from the Center for Lung Research, Dept. of Med. Path. and Molecular Phys. and Biophys., Vanderbilt U. School of Med., Nashville, Tenn. (1989) pp. 278-284.
Burrows, et al. “Eradication of large solid tumors in mice with an immunotoxin directed aganst tumor vasculature”,Proc. Natl. Acad. Sci. USA, (1993) vol. 90: 8996-9000.
Campbell, et al. “Cationic lipids induce changes in the physical properties of the dipalmitoylphosphatidylcholine bilayers”,Biophys. J.,(1996) vol. 70(2): A416 (WP216).
Campbell, et al. “Cationic liposome mediated drug delivery”,Biophys. J.,(1997) vol. 72(2): A303 (WP313).
Campbell, et al. “Biophysical characterization of cationic lipid-paclitaxel complexes”,AAPS PharmSci.,(1998) p. 1360.
Depre, et al. “Neovascularization in human coronary atherosclerotic lesions”,Cathet. Cardiovasc. Diagn.,(1996) vol. 39(3): 215-220.
Felgner, et al. “Gene therapeutics”,Nature, (1991) vol. 349: 351-352.
Felgner, et al. “Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure”,Proc. Natl. Acad. Sci. USA, (1987) vol. 84: 7413-7417.
Folkman, et al. “Induction of angiogenesis during the transition from hyperplasia to neoplasia”,Nature, (1989) vol. 339: 58-61.
Folkman, et al. “Angiogenic factors”,Science, (1987) vol. 235: 442-447.
Gao, et al. “Cationic liposome-mediated gene transfer”,Gene Therapy, (1995) vol. 2: 710-722.
Hanahan, et al. “Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis”,Cell, (1996) vol. 86: 353-364.
Huang, et al. “Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature”,Science, (1996) vol. 275: 547-550.
Isner. “Cancer and atherosclerosis: The broad mandate of angiogenesis”, Circulation, (1999) vol. 99(13): 1653-1655.
Klauber, et al. “Inhibition of angiogenesis and breast cancer in mice be the microtubule inhibitors 2-methoxyestradiol and Taxol™”,CancerResearch, (1997) vol. 57: 81-86.
LASIC,Liposomes: From Physics to Applications, Elsevier, N.Y. (1996) pp. 265-493.
Liposomes: A practical approach, (1990) R.R.C. New (Ed.), IRL Press at Oxford U. Press, NY.
Morishita, et al. “A novel promoter for vascular endothelial growth factor receptor (fit-1) that confers endothelial-specific gene expression”,J. Biol. Chem.,(1995) 270: 27948-27953.
Moulton, et al. “Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice”,Circulation, (1999) vol. 99(13): 1726-1732.
Teifel, et al. “Optimization of transfection of human endothelial cells”,Endothelium, (1997) vol. 3: 21-35.
Vázquez, et al. “METH-1 a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity”,Journal of Biological Chemistry, (1999) vol. 274(33): 23349-23357.
Xu, et al. “Parenteral gene therapy with p53 inhibits human breast tumors in vivo through a bystander mechanism without evidence of toxicity”,Human Gene Therapy, (1997) vol. 8:177-185.
Campbell, et al., “Cationic liposome mediated drug delivery”,Biophys. J.,(1997) vol. 72(2): A303 (WP313).
McLean, et al., “Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice”,Amer. J. Physiology, vol. 1, part 2, 273:H387-H404.
Sharma et al. “ Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes” Pharmaceutical Research, vol. 11, No. 6, 1994.

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