Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1994-07-08
1998-07-07
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560159, 564157, 564159, 536 221, C07C27120, C07C23706, C07C23722
Patent
active
057771537
ABSTRACT:
The present invention is directed to new cationic lipids and intermediates in their synthesis that are useful for transfecting nucleic acids or peptides into prokaryotic or eukaryotic cells. The lipids comprise one or two arginine, lysine or ornithine residues linked to a lipophilic moiety. The lipids form a composition when mixed with polyanions such as nucleic acids. The compositions permit efficient transfer of polyanions into cells without significant toxicity to the cells.
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Lewis Jason G.
Lin Kuei-Ying
Matteucci Mark D.
Wagner Richard W.
Gilead Sciences, Inc.
Muenchau Daryl D.
Raymond Richard L.
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