Cationic lipid compositions targeting angiogenic endothelial...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Reexamination Certificate

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Reexamination Certificate

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07135192

ABSTRACT:
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.

REFERENCES:
patent: 4394448 (1983-07-01), Szoka, Jr. et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 5092885 (1992-03-01), Yamada et al.
patent: 5192744 (1993-03-01), Bouck et al.
patent: 5202352 (1993-04-01), Okada et al.
patent: 5264618 (1993-11-01), Felgner et al.
patent: 5328470 (1994-07-01), Nabel et al.
patent: 5556878 (1996-09-01), Kelly et al.
patent: 5580899 (1996-12-01), Mayhew et al.
patent: 5641755 (1997-06-01), Weichselbaum et al.
patent: 5770581 (1998-06-01), Weichselbaum et al.
patent: 5837283 (1998-11-01), McDonald et al.
patent: 5837682 (1998-11-01), Folkman et al.
patent: 5935937 (1999-08-01), Smith
patent: 5965739 (1999-10-01), Kelly et al.
patent: 6120799 (2000-09-01), McDonald et al.
patent: 6271206 (2001-08-01), Pillai
patent: 6426086 (2002-07-01), Papahadjopoulos
patent: 6756055 (2004-06-01), McDonald et al.
patent: 0 636 363 (1995-02-01), None
patent: 0819758 (1998-01-01), None
patent: WO 91/06309 (1991-05-01), None
patent: WO 91/16024 (1991-10-01), None
patent: WO 93/12240 (1993-06-01), None
patent: WO 93/12756 (1993-07-01), None
patent: WO 93/18751 (1993-09-01), None
patent: WO 93/24640 (1993-12-01), None
patent: WO 93/25673 (1993-12-01), None
patent: WO 95/25543 (1995-09-01), None
patent: WO 95/29242 (1995-11-01), None
patent: WO 95/29242 (1995-11-01), None
patent: WO 00/47235 (2000-08-01), None
Wasan, E. K., Plasmid DNA is protected against ultrasonic cavitation-induced damage when complexed to cationic liposomes., Journal of Pharmaceutical Sciences, 85, # 4, pp. 427-433, Apr., 1996.
Klauber, et al. “Inhibition of angiogenesis and breast cancer in mice be the microtubule inhibitors 2-methoxyestradiol and Taxol™”,CancerResearch, (1997) vol. 57: 81-86.
Isner, “Cancer and atherosclerosis: The broad mandate of angiogenesis”, Circulation, (1999) vol. 99(13): 1653-1655.
Campbell, et al., “Cationic liposome mediated drug delivery”,Biophys. J., (1997) vol. 72(2): A303 (WP313).
McLean, et al., “Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice”,Amer. J. Physiology. vol. 1, part 2, 273:H387-H404.
Brigham, K.L., et al., (1989) “Expression of a Prokaryotic Gene in Cultured Lung Endothelial Cells after Lipofection with a Plasmid Vector,” Am. J. Respir. Cell Mol. Biol. 1: 95-100.
Brigham, K.L., et al. (1989) “Rapid Communication: In vivo Transfection of Murine Lungs with a Functioning Prokaryotic Gene Using a Liposome Vehicle,” from the Center for Lung Research, Dept. of Med. Path. and Molecular Phys. and Biophys., Vanderbuilt U. School of Med., Nashville, Tenn. pp. 278-284.
Burrows, F.J., et al., (1993) “Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature,” Proc. Natl. Acad. Sci. USA 90: 8996-9000.
Felgner, P.L., et al., (1991) “Gene Therapeutics” Nature 349: 351-352.
Felgner, P.L., et al., (1987) “Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure,” Proc. Natl. Acad. Sci. USA 84: 7413-7417.
Folkman, J., et al., (1989) “Induction of angiogenesis during the transition from hyperplasia to neoplasia,” Nature 339: 58-61.
Folkman, J., et al., (1987) “Angiogenic Factors,” Science 235:442-447.
Gao, X., et al., (1995) “Cationic liposome-mediated gene transfer,” Gene Therapy 2: 710-722.
Hanahan, D., et al., (1996) “Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis,” Cell 86: 353-364.
Huang, X., et al., (1997) “Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature,” Science 275: 547-550.
Morishita, K., et al., (1995) “A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression,” J. Biol Chem. 270: 27948-27953.
Xu, M., et al., “Parental Gene Therapy with p53 Inhibits Human Breast Tumors in Vivo Through a Bystander Mechanism Without Evidence of Toxicity,” Human Gene Therapy 8:177-185.
Iwona Wrobel, et al. Biochimica et Biophysica Acta, 1995, vol. 1235, p. 296-304.

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