Cation-exchange support materials and method

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Ion-exchange polymer or process of preparing

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521 31, 210656, C08D 520

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active

048046868

ABSTRACT:
Cation-exchange support materials and methods for producing such materials are disclosed. In making the support materials, first a thin layer of an adsorbate comprising amine groups is adsorbed to an inorganic support material such as silica, alumina or titania. The adsorbed coating is then optionally crosslinked by a crosslinking agent such as epoxy resin or alkyl bromide. At least one amine group of the adsorbed crosslinked coating is then reacted, preferably in the presence of a proton scavenger, with an amount of a hydrophilic reagent sufficient to generate at least one carboxyl group. Alternatively, amine groups of the uncrosslinked adsorbed coating are reacted, preferably in the presence of a proton scavenger, with an amount of a hydrophilic polyfunctional reagent sufficient to simultaneously crosslink said coating and generate carboxyl groups.

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Cation-Exchange High-Performance Liquid Chromatography of Proteins on Poly(Aspartic Acid)-Silica--Alpert--Journal of Chromatography, 266 (1983), 23-37.

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