Compositions – Solvents
Reexamination Certificate
1999-08-27
2003-03-04
Casler, Brian L. (Department: 3763)
Compositions
Solvents
C604S523000, C424S666000, C424S680000, C206S438000, C423S481000
Reexamination Certificate
active
06527979
ABSTRACT:
TECHNICAL FIELD
The field of this invention is vascular disease, particularly vascular diseases characterized by the presence of calcified vascular occlusions.
BACKGROUND OF THE INVENTION
Vascular occlusions, which may be partial or total occlusions, play a prominent role in many types of vascular disease. Many vascular occlusions encountered in the treatment of vascular disease are characterized by having a mineral component, i.e. they are calcified. Calcified vascular occlusions, both partial and total, are found in both peripheral and coronary vascular disease.
A variety of different protocols have been developed for treating vascular diseases characterized by the presence of partial or total occlusions. Such treatment methodologies generally involve mechanical removal or reduction of the size of the occlusion, and include: bypass surgery, balloon angioplasty, mechanical debridement, atherectomy, and the like.
Despite the plethora of different treatment strategies that have been developed for the treatment of vascular diseases associated with vascular occlusions, there are disadvantages associated with each technique, such as tissue damage, invasiveness, etc. For example, restenosis is a common complication that results in arteries in which occlusions have been mechanically removed.
Calcified vascular occlusions pose significant challenges to currently employed treatment methodologies. For example, where the target vascular occlusion is a total occlusion, it is difficult if not impossible to pass a guidewire through the occlusion, which step is required for many of the currently used procedures. While bypass grafts are sometimes available as alternatives in such instances, bypass procedures have their own risks and complications. Furthermore, if there is no appropriate anastomosis site available, amputation is often the only alternative.
As such, there is continued interest in the development endovascular methods of treating vascular occlusions. Of particular interest would be the development of methods and devices suitable for use in the treatment of calcified vascular occlusions.
Relevant Literature
U.S. Patents of interest include: U.S. Pat. Nos. 4,445,892; 4,573,966; 4,610,662; 4,636,195; 4,655,746; 4,690,672; 4,824,436; 4,911,163; 4,976,733; 5,059,178; 5,090,960; 5,167,628; 5,195,955; 5,222,941; 5,370,609; 5,380,284; 5,443,446; 5,462,529; 5,496,267 and 5,785,675. See also: Koltun et al., Arch. Surg. (August 1987) 122:901-905; Olin et al., Ann. Emerg. Med. (November 1988) 17:1210-1215; Hargrove et al., Surgery (December 1982) 92:981-993; and Rickard et al., Cardiovascular Surg. (December 1997) 5:634-640. See also Peripheral Endovascular Interventions, 2
nd
ed. (White & Fogarty eds., Springer, N.Y.)(1996) pp 565-576.
SUMMARY OF THE INVENTION
Catheter systems and methods are provided for enhancing fluid flow, i.e. blood flow, through a vascular site occupied by a vascular occlusion. The subject catheter systems include at least an aspiration catheter and at least one of a total occlusion insert catheter and a partial occlusion insert catheter, where the insert catheters are capable of being slidably moved within the aspiration lumen of the aspiration catheter. In practicing the subject methods, a surface of the vascular occlusion is flushed with an acidic dissolution fluid using the subject catheter systems for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter systems and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.
REFERENCES:
patent: 3859228 (1975-01-01), Morishita et al.
patent: 3892818 (1975-07-01), Scharfe et al.
patent: 4065366 (1977-12-01), Oda et al.
patent: 4202760 (1980-05-01), Storey et al.
patent: 4208404 (1980-06-01), Cowan
patent: 4329994 (1982-05-01), Cooper
patent: 4336881 (1982-06-01), Babb et al.
patent: 4445892 (1984-05-01), Hussein et al.
patent: 4573966 (1986-03-01), Weikl et al.
patent: 4610662 (1986-09-01), Weikl et al.
patent: 4636195 (1987-01-01), Wolinsky
patent: 4655746 (1987-04-01), Daniels et al.
patent: 4690672 (1987-09-01), Veltrup
patent: 4824436 (1989-04-01), Wolinsky
patent: 4838881 (1989-06-01), Bennett
patent: 4911163 (1990-03-01), Fina
patent: 4976733 (1990-12-01), Girardot
patent: 5059178 (1991-10-01), Ya
patent: 5090960 (1992-02-01), Don Michael
patent: 5149330 (1992-09-01), Brightbill
patent: 5167623 (1992-12-01), Cianci et al.
patent: 5167628 (1992-12-01), Boyles
patent: 5195955 (1993-03-01), Don Michael
patent: 5207648 (1993-05-01), Gross
patent: 5222941 (1993-06-01), Don Michael
patent: 5370609 (1994-12-01), Drasler et al.
patent: 5380284 (1995-01-01), Don Michael
patent: 5443446 (1995-08-01), Shturman
patent: 5462529 (1995-10-01), Simpson et al.
patent: 5496267 (1996-03-01), Drasler et al.
patent: 5542937 (1996-08-01), Chee et al.
patent: 5594125 (1997-01-01), Seyschab et al.
patent: 5785675 (1998-07-01), Drasler et al.
patent: 5833650 (1998-11-01), Imran
patent: 5942410 (1999-08-01), Lam et al.
patent: 6013068 (2000-01-01), Spiegelhalter
patent: 6123966 (2000-09-01), Kross
patent: 6156350 (2000-12-01), Constantz
patent: 6242388 (2001-06-01), Sharma et al
Hargrove III et al. (Dec. 1982), “Treatment of Acute Peripheral Arterial and Graft Thromboses with Low-Dose Streptokinase,”Surgery, vol. 92(6):981-993.
Koltun et al. (Aug. 1987), “Thrombolysis in the Treatment of Peripheral Arterial Vascular Occlusions,”Arch Surg, vol. 122:901-905.
Olin et al. (Nov. 1988), “Thrombolytic Therapy in the Treatment of Peripheral Arterial Occlusions,”Annals of Emergency Medicine, vol. 17:1210/125-1215/130.
Rickard et al. (Dec. 1997), “Limitations of Intra-Arterial Thrombolysis,”Cardiovascular Surgery, vol. 5(6):634-640.
Constantz Brent R.
Johansson Peter K.
McGurk Erin
Bozicevic, Field & Francis
Casler Brian L.
Corazon Technologies, Inc.
Field Bret E.
Thissell Jeremy
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