Cathespin O protease

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 435325, 4352523, 43525411, 536 235, C12N 121, C12N 1515, C12N 1563, C12P 2102

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active

057363579

ABSTRACT:
The invention relates to cathepsin O proteins, nucleic acids, and antibodies.

REFERENCES:
patent: 5501969 (1996-03-01), Hastings et al.
Drake, F. et al., "Identification of a Novel Osteoclast-Selective Human Cysteine Proteinase," Journal of Bone and Mineral Research, 9(Supp. 1):S177 (Abstract A110) (Aug. 1994).
Tezuka, K., et al., "Molecular Cloning of a Possible Cysteine Proteinase Predominantly Expressed in Osteoclasts", The Journal of Biological Chemistry, 269(2):1106-1109, (1994).
Delaisse, J.M., et al., "Inhibition of Bone Resorption in Culture by Inhibitors of Thiol Proteinases", The Biochemical Society, 192:365-368, (1980).
Delaisse, J.M., et al., "Collagenolytic Cysteine Proteinases of Bone Tissue", The Biochemical Society, 279:167-174, (1991).
Everts, V., et al., "Effects of the Proteinase Inhibitors Leupeptin and E-64 on Osteoclastic Bone Resorption", Calcif Tissue Int., 43:172-178, (1988).
Sasaki, T., et al., "Cystein-Proteinase Localization in Osteoclasts: An Immunocytochemical Study", Cell Tissue Res., 271:177-179, (1993).
Eeckhout Y., et al., "Possible Role and Mechanism of Action of Dissolved Calcium .sub.-- The Degradation of Bone Collagen by Lysosomal Cathepsins and Collagenase", Biochem J., 272:529-532, (1990).
Van Noorden, C.J.F., et al., "Cysteine Proteinase Activity in Arthritic Rat Knee Joints and the Effects of a Selective Systemic Inhibitor, Z-Phe-AlaCH.sub.2 F", The Journal of Rheumatology, 15(10):1525-1535, (1988).
Delaisse, J.M., et al., "Mechanism of Mineral Solubilization and Matrix Degradation in Osteoclastic Bone Resorption", Biology and Physiology of the Osteoclast, Ch. 14:289-314, (1991).
Shi, G.P., et al., "Molecular Cloning of Human Cathepsin O, a Novel Endoproteinase and Homologue of Rabbit OC2", FEBS Letters, 357:129-134, (1995).
Inaoka, T., et al., "Molecular Cloning of Human cDNA for Cathepsin K: Novel Cysteine Proteinase Predominantly Expressed in Bone", Biochem. Biophys. Res. Comm., 206(1):89-96 (1995).
Wiederanders et al., J. Biol. Chem. 267:13708-13713 (1992).
Tsukuba et al., J. Biol. Chem. 268:7276-7282 (1993).

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