Cathepsin cysteine protease inhibitors and their use

Details Cathepsin cysteine protease inhibitors and their use Cathepsin cysteine protease inhibitors and their use

2003-12-11

2009-10-20

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S122000

Reexamination Certificate

active

07605159

ABSTRACT:
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition this invention also discloses processes for the preparation of such inhibitors.

REFERENCES:
patent: WO01/09110 (2001-02-01), None
patent: WO01/49288 (2001-07-01), None
patent: WO 01/68645 (2001-09-01), None
patent: WO 02/069901 (2002-09-01), None
patent: WO03/048123 (2003-06-01), None
patent: WO2004/056324 (2004-07-01), None
Leroy et al., Expert Opinion on Therapeutic Patents, vol. 14(3), pp. 301-311, (2004).
Vasiljeva et al., Current Pharmaceutical Design, vol. 13, pp. 387-403 (2007).
Palermo et al., Trends in Pharmacological Sciences, vol. 29, No. 1, pp. 22-28, (2007).
Cai et al. “Cathepsin K Inhibitors 2000-2004” Expert Opinion Ther. Patents. 2005 (15) 33-48.

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