Cathepsin cysteine protease inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Reexamination Certificate

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Details

C514S252010, C514S357000, C514S365000, C544S393000, C544S400000, C546S330000, C548S204000, C558S404000, C558S414000, C558S431000, C558S434000

Reexamination Certificate

active

07375134

ABSTRACT:
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

REFERENCES:
patent: 2005/0014941 (2005-01-01), Black et al.
patent: 2005/0182096 (2005-08-01), Link et al.
patent: 2006/0111440 (2006-05-01), Gauthier et al.
patent: WO 00/55126 (2000-09-01), None
patent: WO 00/49007 (2003-08-01), None
Alessandro Volonterio, et al. “Synthesis of Partially Modified Retro and Retroinverso Ψ[NHCH(CF3)]-Peptides,” Organic Letters 2000, vol. 2, No. 13, 1827-1830.
Alessandro Volonterio, et al. “Solution/solid-phase synthesis of partially modified retro-ψ [NHCH(CF3)]-peptidyl hydroxamates,” Tetrahedron Letters 42 (2001), 3141-3144.
Alessandro Volonterio, et al. “Solid-phase synthesis of partially-modified retro and retro-inverso Ψ[NHCH(CF3)]-peptides,” Tetrahedron Letters 41 (2000), 6517-6521.
Ishii, et al. “Asymmetric Addition Reactions of Grignard Reagents to Chiral Fluoral Hemiacetal: Asymmetric Synthesis of 1-Substituted-2,2,2,-Trifluoroethylamines,” Synlett, Dec. 1997, 1381-1382.
Ishii, et al. “Stereospecific Reduction with Retention of Chiral Fluoral-derived 1,3-Oxazolidines with LiAlH4: Asymmetric Synthesis of 1-Substituted 2,2,2-Trifluoroethylamines,” Chem. Letters 1998, 119-120.

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