Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1997-06-09
2000-05-23
Hobbs, Lisa J.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435219, 435226, 435325, 424 9463, 424 9465, 530412, 536 232, 536 231, 5363201, C12N 948, C12N 950, C12N 964, C12N 1500
Patent
active
060664886
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression vectors for the production of purified RCP, antibodies capable of binding specifically to RCP, hybridization probes or oligonucleotides for the detection of RCP-encoding nucleotide sequences, genetically engineered host cells for the expression of RCP, diagnostic tests for activation of monocyte/macrophages based on RCP-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
REFERENCES:
patent: 5366862 (1994-11-01), Venton et al.
Tsuchiya et al., "Establishment and Characterization of a Human Acute Monocytic Leukemia Cell Line (THP-1)" Int J Cancer 26:171-176 (1980).
Auwerx, J., "The human leukemia cell line, THP-1: A multifacetted model for the study of monocyte-macrophage differentiation" Experientia 47:22-28 (1991).
Cochran et al., "Regulation of interleuikin-1.beta. and tumor necrosis factor secretion by the human monocytic leukemia cell line, THP-1" Agents and Actions 27:271-273 (1989).
Kominami et al., "The Primary Structure and Tissue Distribution of Cathepsin C" Biol Chem 373:367-373 (1992).
Kuribayashi et al., "Endopeptidase Activity of Cathepsin C, Dipeptidyl Aminopeptidase I, from Bovine Spleen" J Biochem 113:441-449 (1993).
Muno et al., "Processing and Transport of the Precursor of Cathepsin C during Its Transfer into Lysosomes" Arch Biochem Biophy 396:103-110 (1993).
Tezuka et al., "Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts" Abstract available only, J Biol Chem 269 (2) :1106-1109 (1994).
Ishidoh et al., "Molecular Cloning of cDNA for Rat Cathepsin C" J. Biol. Chem. 266 (25) :16312-16317 (1991).
Paris et al., "Molecular cloning and sequence analysis of human preprocathepsin C" FEBS Lett 369:326-330 (1995).
Dolenc et al., "Oligomeric structure and substrate induced inhibition of human cathepsin C" J. Biol. Chem. 270 (37) :21626-21631 (1995).
McGuire, M. et al., Arch. Biochem. Biophys., vol. 295, No. 2, pp. 280-288, 1992.
Braxton Scott Michael
Coleman Roger
Seilhamer Jeffrey J.
Hamlet-Cox Diana
Hobbs Lisa J.
Incyte Pharmaceuticals Inc.
Tung Peter P.
LandOfFree
Cathepsin C homolog does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cathepsin C homolog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cathepsin C homolog will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1836137