Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-04-19
1997-06-10
Elliott, George C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 221, 536 231, 536 243, 536 2431, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
056374623
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression vectors for the production of purified RCP, antibodies capable of binding specifically to RCP, hybridization probes or oligonucleotides for the detection of RCP-encoding nucleotide sequences, genetically engineered host cells for the expression of RCP, diagnostic tests for activation of monocyte/macrophages based on RCP-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
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Braxton Scott M.
Coleman Roger
Seilhamer Jeffrey J.
Billings Lucy J.
Elliott George C.
Fredman Jeffrey
Incyte Pharmaceuticals Inc.
Luther Barbara J.
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