Cathepsin and methods and compositions for inhibition thereof

Details Cathepsin and methods and compositions for inhibition thereof Cathepsin and methods and compositions for inhibition thereof

1997-05-02

1999-01-12

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 4352402, 530324, A61K 3800, A61K 3806

Patent

active

058589821

ABSTRACT:
Methods for inhibiting the secretion of .beta.-amyloid peptide (.beta.AP) from cells comprise administering to the cells certain compounds which inhibit the activity of an approximately 31 kD protease involved in .beta.AP secretion. The 31 kD protease has been designated Cathepsin Y. Screening methods for .beta.AP inhibitors rely on determining the activity of test compounds in the presence of Cathepsin Y and a suitable peptide substrate. This invention is also directed to a nucleic acid sequence that encodes Cathepsin Y and the expression and isolation of Cathepsin Y.

REFERENCES:
patent: 4666829 (1987-05-01), Glenner et al.
patent: 5011472 (1991-04-01), Aebisher
patent: 5023252 (1991-06-01), Hseih
patent: 5164295 (1992-11-01), Kisilevsky et al.
patent: 5221607 (1993-06-01), Cordell et al.
patent: 5348963 (1994-09-01), Gandy et al.
patent: 5441870 (1995-08-01), Seubert et al.
patent: 5478857 (1995-12-01), Clemens et al.
patent: 5523295 (1996-06-01), Fasman
patent: 5523314 (1996-06-01), Bue-Valleskey et al.
Patel S.V. Pharmacotherapy of cognitive impairment in Alzheimer's disease: a review. J. Geriatr. Psychiatry Neurol. 8, 81-95 (see copy in parent case), 1995.
Glenner et al., Biochem. Biophys. Res. Commun. 120:885-890 (1984).
Selkoe, Neuron 6:487 (1991).
Goate et al., Nature 349:704-706 (1991).
Chartier Harlan et al., Nature 353:844-846 (1991).
Murrell et al., Science 254:97-99 (1991).
Mullan et al., Nature Genet 1:345-347 (1992).
Younkin et al., Science 259:514-516 (1993).
Kang et al., Nature 325:733-736 (1987).
Ponte et al., Nature 331:525-527 (1988).
Tanzi et al., Nature 331:528-530 (1988).
Kitaguchi et al., Nature 331:530-532 (1988).
Hardy, Nature Genet. 1:233-234 (1992).
J. Gen. Chem. USSR 34:1021 (1964).
J. Org. Chem. 49:2279 (1984).
Luly et al., Journal of Organic Chemistry, 52(8):1487 et seq. (1987).
Green et al., J. Biol. Chem., "Peptidyl Diazomethyl Ketones are Specific Inactivators of Thiol Proteinases", 256(4):1923-1928 (1981).
Citron et al., Nature, 360:672-674 (1992).
Hansen et al., J. Immun. Meth., 119:203-210 (1989).
Simons et al., JACS, 98:7098-7099 (1976).
Frohman et al., (1988), PNAS USA 85:8998-9002).
Patel et al., Psychiatry Neurol., 8:81-95 (1995).

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