Catechol diacetate derivatives for inducing the production of ne

Details Catechol diacetate derivatives for inducing the production of ne Catechol diacetate derivatives for inducing the production of ne

1990-02-20

1991-01-15

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

A61K 31235

Patent

active

049854585

ABSTRACT:
A pharmaceutical composition for the treatment of regressive disorders of the central nervous system treatable by inducing the production and secretion of nerve growth factor, containing as an active ingredient a catechol derivative of the formula ##STR1## where R.sub.6 is a lower alkyl group having 2 to 5 carbon atoms. The catechol derivatives provide preventative and remedial effects for regressive disorders in the central nervous system including senile dementia of the alzheimer type.

REFERENCES:
patent: 3631227 (1971-12-01), Kablaoui et al.
patent: 4559328 (1985-12-01), Smerbeck
patent: 4578210 (1986-03-01), Praefcke et al.
patent: 4593121 (1986-06-01), Okamoto et al.
patent: 4608391 (1986-08-01), Ginos
The Journal of Biological Chemistry, vol. 261, No. 13, May 1986, Y. Furukawa et al., "Catecholamines Induce an Increase in Nerve Growth Factor Content in the Medium of Mouse L-M Cells", p. 6039, abstract; p. 6043, table I; p. 6044, right column, lines 35-46.

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