Catechol derivatives, and preventive and remedial preparations f

Details Catechol derivatives, and preventive and remedial preparations f Catechol derivatives, and preventive and remedial preparations f

1990-10-31

1992-04-07

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514465, 549274, 549296, 549343, A61K 31335, C07D31916

Patent

active

051029065

ABSTRACT:
Catechol derivatives which relate to the production of nerve growth factor in particular tissues of brain are disclosed.
Methods for the synthesis, data on the physiological activity, and data on the toxicity of these derivatives as well as examples of preparation for their administration are also disclosed.
The disclosed derivatives provide preventive and remedial effect for regressive disorders in the central nervous system including senile dementia of Alzheimer type.

REFERENCES:
patent: 4183861 (1980-01-01), Maggioni
patent: 4241097 (1988-12-01), Sprecker et al.
patent: 4427666 (1984-01-01), Mues et al.
patent: 4681955 (1987-07-01), Marhold
patent: 4761491 (1988-08-01), Heistand, II
patent: 4803290 (1989-02-01), Burke et al.
Nakayama et al. "Preparation and testing of alkylcatechal and alkylbenzodioxane derivatives as nerve growth factor stimulants for treatment of alzheimer's disease"; CA 109 54784w (1988).
Kersaint et al. "Abnormal Thermal Reaction Between Pyrocatechol and Ethyl Phenylnalonate" CA 63 6902h (1965).
The Journal of Biological Chemistry, (1986), 261, pp. 6039-6047, "Catecholamines Induce an Increase in Nerve Growth Factor Content in the . . . " Furukawa et al.
Proc. Natl. Acad. Sci., (1986), 83, pp. 1950-1954, "Nerve Growth Factor Receptor Molecules in Rat Brain", Taniuchi et al.

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