Catechol derivatives, a process of preparation thereof, and ther

Details Catechol derivatives, a process of preparation thereof, and ther Catechol derivatives, a process of preparation thereof, and ther

1989-05-23

1991-05-07

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514568, 514570, 514712, A61K 3110, A61K 31235

Patent

active

050137565

ABSTRACT:
This invention relates to catechol derivatives having the general formula ##STR1## wherein R represents various substituents, to a process for the preparation of the same comprising reacting S-(3,4-dihydroxyphenyl)-isothiourea, which has the formula II, with a tosylate of the general formula III ##STR2## and to therapeutical compositions wherein the active ingredient is one of these compounds.

REFERENCES:
patent: 2549118 (1951-04-01), Newby
patent: 3148997 (1964-09-01), Hemwall
patent: 3282979 (1966-11-01), Reifschneider
patent: 3751483 (1973-08-01), Cisney
patent: 3930862 (1976-01-01), Tsubota
patent: 4120866 (1978-10-01), Winkler
patent: 4661505 (1987-04-01), Marshall et al.
patent: 4785004 (1988-11-01), Von Sprecher et al.
Corey et al., JACS, 1982, 104, 1750-1754.

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