Catechol derivative, pharmaceutical composition containing...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S131000

Reexamination Certificate

active

07923462

ABSTRACT:
The present invention provides compounds represented by general formula (I):or pharmaceutical acceptable salts thereof, wherein R1and R2are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

REFERENCES:
patent: 4871753 (1989-10-01), Rohr
patent: 5389653 (1995-02-01), Bernauer et al.
patent: 62-240649 (1987-10-01), None
patent: 63-162680 (1988-07-01), None
patent: 2007/013830 (2007-02-01), None
patent: 2007/117165 (2007-10-01), None
Learmonth et al, caplus an 2007:117521.
D. A. Learmonth, et al., “Synthesis of 1-(3,4-Dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and Derivatives as Potent and Long-Acting Peripheral Inhibitors of Catechol-O-methyltransferase,” J. Med. Chem., 2002, pp. 685-695, vol. 45, American Chemical Society.

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