Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-04-12
2011-04-12
Loewe, Sun Jae Y (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S131000
Reexamination Certificate
active
07923462
ABSTRACT:
The present invention provides compounds represented by general formula (I):or pharmaceutical acceptable salts thereof, wherein R1and R2are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
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Learmonth et al, caplus an 2007:117521.
D. A. Learmonth, et al., “Synthesis of 1-(3,4-Dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and Derivatives as Potent and Long-Acting Peripheral Inhibitors of Catechol-O-methyltransferase,” J. Med. Chem., 2002, pp. 685-695, vol. 45, American Chemical Society.
Inoue Hitoshi
Ishikawa Takehiro
Kobayashi Satoko
Shiohara Hiroaki
Tanaka Nobuyuki
Kissei Pharmaceutical Co. Ltd.
Loewe Sun Jae Y
Sughrue & Mion, PLLC
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