Cataplasms containing vitamin C or its derivative

Details Cataplasms containing vitamin C or its derivative Cataplasms containing vitamin C or its derivative

2001-04-25

2003-03-04

Venkat, Jyothsan (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Wearing apparel, fabric, or cloth

C424S078030, C424S401000, C424S449000, C424S684000, C424S583000, C424S690000, C514S494000, C514S944000

Reexamination Certificate

active

06528077

ABSTRACT:

TECHNICAL FIELD
The present invention relates to a cataplasm containing vitamin C or a derivative thereof. More specifically, the present invention relates to a cataplasm comprising a crosslinked polymer gel containing vitamin C or a derivative thereof and a support.
BACKGROUND ART
Water-soluble adhesive ingredients are widely and routinely used today in conventional cataplasms such as antiphlogistic and analgetic cataplasms (plaster for external skin), moisture retention cosmetic pack and cooling gel sheets. They are formed by mixing kaolin or glycerin as a base with water-soluble polymer materials such as sodium polyacrylate or carboxymethylcellulose sodium, various active ingredients, water and so forth, and molding them, while its shape-retainability is secured by using a metal crosslinking agent.
DISCLOSURE OF THE INVENTION
Vitamin C or a derivative thereof has long been known to have an effect for preventing abnormal pigmentation by inhibiting skin melanin production, and it has been attempted to add vitamin C or a derivative thereof to cataplasms such as a cosmetic pack as an active ingredient for obtaining a skin-whitening effect. However, there is a problem that, when vitamin C or a derivative thereof is added to an adhesive cataplasm, a stable gel cannot be formed since water-soluble polymers are not crosslinked due to interaction of vitamin C or a derivative thereof and a metal crosslinking agent and thus the materials cannot be molded as a cataplasm.
As a result of efforts devoted to solve this problem, it was found that a gel-like cataplasm having favorable shape-retainability could be obtained by blending two kinds of substances selected from magnesium aluminometasilicate, dried aluminum hydroxide gel and aluminum chloride as crosslinking agents with a mixture of a water soluble polymer, glycerin, kaolin, water and so forth, and thus the present invention was accomplished.
That is, the present invention provides a cataplasm comprising crosslinked polymer gel containing vitamin C or a derivative thereof and a support, wherein the gel is formed by crosslinking a polymer with two kinds of substances selected from magnesium aluminometasilicate, dried aluminum hydroxide gel and aluminum chloride.
In the present invention, the polymer preferably consists of one or more kinds of materials selected from the group consisting of gelatin, gum arabic, glucomannan, xanthan gum, tragacanth gum, polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, carboxymethylcellulose sodium, hydroxypropylcellulose, methylcellulose, ethylcellulose, methyl vinyl ether/maleic anhydride copolymer, sodium polyalginate and polyethylene oxide.
In the present invention, the content of vitamin C or a derivative thereof is preferably 0.01-10 parts by weight per 100 parts by weight of the crosslinked polymer gel.
In the present invention, the sum of the contents of the two kinds of crosslinking agents selected from magnesium aluminometasilicate, dried aluminum hydroxide gel and aluminum chloride is preferably 0.5-5 parts by weight per 100 parts by weight of the crosslinked polymer gel.
In the present invention, the polymer content is preferably 1-40 parts by weight per 100 parts by weight of the crosslinked polymer gel.
Further, pH of the gel used for the cataplasm of the present invention is preferably in the range of 5.5-8.5. Moreover, the gel of the cataplasm of the present invention preferably further contains a polyhydric alcohol.
The cataplasm of the present invention containing vitamin C or a derivative thereof has excellent shape-retainability, since gel is formed by crosslinking of the polymer due to the inclusion of the two kinds of substances selected from magnesium aluminometasilicate, dried aluminum hydroxide gel and aluminum chloride.
Hereafter, the present invention will be explained in more detail.
The present invention provides a cataplasm comprising crosslinked polymer gel containing vitamin C or a derivative thereof and a support, wherein the gel is formed by crosslinking a polymer with two kinds of substances selected from magnesium aluminometasilicate, dried aluminum hydroxide gel and aluminum chloride. That is, the cataplasm of the present invention is characterized by containing vitamin C or a derivative thereof, two kinds of substances selected from magnesium aluminometasilicate, dried aluminum hydroxide gel and aluminum chloride and polymer. This cataplasm can provide various effects of vitamin C or a derivative thereof due to the inclusion of vitamin C or a derivative thereof as an active ingredient, and can show superior shape-retainability and adhesion since the polymer is crosslinked to form a gel even in the presence of vitamin C or a derivative thereof due to the inclusion of two kinds of substances selected from magnesium aluminometasilicate, dried aluminum hydroxide gel and aluminum chloride as crosslinking agents. Each of these ingredients will be explained below.
<1> Vitamin C or Derivative Thereof
The cataplasm of the present invention containing crosslinked polymer gel contains vitamin C, i.e., L-ascorbic acid, or a derivative of L-ascorbic acid. Examples of derivatives of L-ascorbic acid include various salts of L-ascorbic acid such as sodium L-ascorbate and L-ascorbyl magnesium phosphate, esters such as L-ascorbyl palmitate, L-ascorbyl stearate and isopropyl vitamin C and so forth. These vitamin C and derivatives thereof can be used each alone, or as a combination of two or more kinds of them. The amount thereof is preferably 0.01-10 parts by weight, more preferably 1-5 parts by weight, per 100 parts by weight of the crosslinked polymer gel. Since the cataplasm of the present invention contains vitamin C or a derivative thereof, there can be obtained various effects derived from vitamin C, for example, a skin-whitening effect obtained by inhibition of skin melanin production and so forth. As described above, the cataplasm of the present invention contains vitamin C or a derivative thereof as an active ingredient, but can also contain other active ingredients. Preferred examples of such active ingredients include sodium hyaluronate, vitamin A, collagen and so forth.
<2> Polymer Material
The cataplasm of the present invention contains a polymer. Examples of the polymer include natural polymers such as gelatin, gum arabic, glucomannan, xanthan gum and tragacanth gum, polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, cellulose derivatives such as carboxymethylcellulose sodium, hydroxypropylcellulose, methylcellulose and ethylcellulose, water-soluble synthetic polymers such as methyl vinyl ether/maleic anhydride copolymer, sodium polyalginate and polyethylene oxide and so forth. The molecular weight of these polymers is not particularly limited.
These polymers may be used each alone or as a combination of two or more kinds of them. Among these polymers, polyacrylic acid and sodium polyacrylate added with other polymers are preferably used. The amount of the polymer can be appropriately selected depending on the kind of polymer to be selected, but it is preferably 1-40 parts by weight, more preferably 5-20 parts by weight, per 100 parts by weight of the crosslinked polymer gel. A cataplasm having favorable shape-retainability and adhesion can be prepared by blending such an amount of the polymer.
<3> Crosslinking Agent
The cataplasm of the present invention containing crosslinked polymer gel contains two kinds of substances selected from magnesium aluminometasilicate, dried saluminum hydroxide gel and aluminum chloride as crosslinking agents.
The combination of magnesium aluminometasilicate, dried aluminum hydroxide gel and aluminum chloride for use in the present invention can be appropriately selected depending on the attaching site or desired adhesion of products. As magnesium aluminometasilicate, for example, Neusilin available from Fuji Chemical Industry Co., Ltd. can be used. As dried aluminum hydroxide gel, the dried aluminum hydroxide gel avail

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