Catalytic stereoselective glycosylation process for preparing 2'

Details Catalytic stereoselective glycosylation process for preparing 2' Catalytic stereoselective glycosylation process for preparing 2'

1993-04-07

1995-06-20

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 276, 536 2761, 536 2762, 536 2763, 536 2781, 536 281, 536 283, 536 284, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, C07H 1900

Patent

active

054261830

ABSTRACT:
A catalytic stereoselective glycosylation process for preparing beta- and alpha-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides involving reacting an alpha- or beta- anomer enriched 2-deoxy-2,2-difluorocarbohydrate or 2-deoxy-2-fluorocarbohydrate with at least a molar equivalent of a nucleobase derivative in an inert solvent and in the presence of a catalyst.

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