Catalytic reduction of organic carbonyls

Details Catalytic reduction of organic carbonyls Catalytic reduction of organic carbonyls

1990-11-21

1994-02-15

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548400, 548578, 562400, 568814, 568831, C07P20706, C07P20720, C07C 3322, C07C 29132, C07C 29147

Patent

active

052868788

ABSTRACT:
A process is provided whereby organic carbonyl substrates, including esters, ketones and amides, are reduced in a reaction with a silane reducing reagent and a catalyst. Effective catalysts broadly include those which consist of a group 4, 5 or 6 metal which either: a) is in less than its maximum oxidation state or is capable of being converted to a complex in less than its maximum oxidation state; and/or is a group 4, 5 or 6 metal hydride. Exemplary catalysts include titanium-containing catalysts such as (bis trimethylphosphine) titanocene, trimethyl phosphine adduct of a (hydrido) silyl complex of titanocene, titanocene dichloride and titanocene monochloride.

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