Catalytic metathesis of secondary amides

Details Catalytic metathesis of secondary amides Catalytic metathesis of secondary amides

2008-12-01

2011-10-18

Davis, Brian J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S170000, C564S179000, C564S182000, C564S218000, C564S219000

Reexamination Certificate

active

08039669

ABSTRACT:
The invention provides methods and reagents for the metathesis of secondary amides via a transacylation mechanism employing catalytic quantities of an imide initiator and a Brønsted base. Equilibrium-controlled exchange between various amide reactant pairs is demonstrated for substrates bearing a variety of N-alkyl and N-aryl substituents.

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