Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1995-06-05
1999-09-21
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530344, 530399, 530409, 530410, 435 681, 435117, 435119, 435193, C07K 1706
Patent
active
059555858
ABSTRACT:
Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention. The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain. The conjugates are for use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell-specific ligands, such as hormones, growth factors or tumor-specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors.
REFERENCES:
patent: 4876190 (1989-10-01), Rectenwald
patent: 5567687 (1996-10-01), Magda et al.
Boxer et al., "Chlorophyl-Amino Acid Interactions in Synthetic Models" (1981) v. 21 N. 4, pp. 259-264.
Zubay, "Biochemistry" (1993) pp. 64-66.
Biotech Abs 88-11013 Michalski et al JA Chem Soc. (1988) 110; 17, 5881-91.
Fiedor Leszek
Salomon Yoram
Scherz Avigdor
Delaney Patrick R.
Tsang Cecilia J.
Yeda Research and Development Co. Ltd.
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