Catalytic asymmetric reduction of trisubstituted olefins

Details Catalytic asymmetric reduction of trisubstituted olefins Catalytic asymmetric reduction of trisubstituted olefins

1993-07-12

1995-08-15

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564343, 564391, 568630, 570250, 585266, C07C21127, C07C 4320, C07C 43205, C07C 2502, C07C 511

Patent

active

054421195

ABSTRACT:
A catalytic asymmetric reduction process, which, by hydrogenating trisubstituted olefins, yields a corresponding organic compound having a high level of enantiomeric purity is disclosed. The reduction process utilizes a chiral metal catalyst that includes a metal or metal complex that is selected from groups 3, 4, 5, or 6, lanthanides and actinides. Moreover, the process uses hydrogen as the stoichiometric reducing agent and may be carried out at pressures ranging from about 1 to 200 atmospheres.

REFERENCES:
Catalytic Asymmetric Synthesis, Iwao Ojima, Ed., Ch. 1, pp. 1-39 (1993, VCH Publishers, Inc.).
"Complexes with Chiral Alkylcuclopentadienyl Ligands for Homogenous Catalytic Asymmetric Hydrogenation of 2-Phenyl-1-butene", Cesarroti et al., Agnew. Chem. Int. Ed. Engl. (1979) 18:779-780.
"Syntheses of [Ethylene-1,2bis(.eta..sup.5 -4,5,6,7-tetrahydro-1-indenyl)]zirconium and hafnium Hydride Complexes. Improved Syntheses of the Corresponding Dichlorides", Grossman et al., Organmetallics, (1991) 10:1501-1505.
"Chiral Metal Complexes as Discriminating Molecular Catalysts", Noyori, Science (1990), 248:1194-1199.
"Chiral Organolanthanide Complexes for Enantioselective Olefin Hydrogenation", Conticello et al., J. Am. Chem. Soc. (1992) 114:2761-2762.
"Recent Advances in Catalytic Asymmetric Reactions Promoted By Transition Metal Complexes," Ojima et al., Tetrahedron (1989) vol. 45, No. 22:6901-6939.
"Synthesis and Asymmetric Reactivity of Enantiomerically Pure Cyclopentadienylmetal Complexes Derived from the Chiral Pool", Halterman, et al., II Organometallics (1988), vol. 7, No. 4:883-892.
"A Designed Enantiomerically Pure, Fused Cyclopentadienyl Ligand with C.sub.2 Symmetry: Synthesis and Use in Anantioselective Titanocene-Catalyzed Hydrogenations of Alkenes", Halterman et al., I J. Am. Chem. Soc. (1987) 109:8105-8107.
Broene et al, J. Am. Chem. Soc., vol. 115, pp. 12569-12570 (1993).
Takaya et al, J. Am. Chem. Soc., vol. 109, pp. 1596-1597 (1987).

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