Catalytic asymmetric hydrogenation

Details Catalytic asymmetric hydrogenation Catalytic asymmetric hydrogenation

1978-09-05

1981-05-05

Sneed, Helen M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260429R, C07F 968

Patent

active

042658276

ABSTRACT:
Process for the homogeneous catalytic hydrogenation of .alpha.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.beta.-acylamido-acrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum.
This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center.
This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.

REFERENCES:
patent: 3849480 (1974-11-01), Knowles et al.
patent: 4124533 (1978-11-01), Knowles et al.
Chemical Abstracts 67 104724p (1967).
Chemical Abstracts 81 169608n(1974).

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