Catalytic antibody with primary amine cofactor

Details Catalytic antibody with primary amine cofactor Catalytic antibody with primary amine cofactor

1995-04-05

1996-11-19

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

4351885, C12Q 125, C12N 900

Patent

active

055761747

ABSTRACT:
Antibodies raised against the quaternary piperidinium haptens are shown to catalyze the aldol stereoselective addition of acetone to aldehydes using the primary benzylamine as a cofactor.

REFERENCES:
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Wagner, J., et al. (1995) Science 270, 1797-1800.
Hupe et al. Enzyme Mechanisms, Ed. M. I. Page and A. Williams, 1987, pp. 317-344.
Fessner et al. Kontakte (vol. 3), 3-9 (1992).
Hupe et al. New Comprehensive Biochemistry, vol. 6, The Chemistry of Enzyme Action, Ed. M. I. Page, Elsevier, Amsterdam, 1984, Chapter 8, pp. 271-301.
Johnsson et al. Nature, 365, p. 530 (1993).
Reymond et al. Angew. Chem. Intl. 30, 1711, (1991).
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Reymond et al. Angew. Chem. Intl. 33, 475 (1994).
Reymond et al. J. Am. Chem. Soc. 115, 3909 (1993).

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