Catalytic antibody/substrate intermediates

Details Catalytic antibody/substrate intermediates Catalytic antibody/substrate intermediates

1998-03-31

1999-11-16

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435148, 4351885, C12P 726, C12P 1300

Patent

active

059856262

ABSTRACT:
Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapten complex. The resultant catalytic antibodies employ a catalytic mechanism which mimics the catalytic mechanism employed by natural class I aldolase enzymes.

REFERENCES:
patent: 5571681 (1996-11-01), Janda
Wagner, J. et al. (1995) Science 270, 1797-1800.
Lerner, R. A., et al. (1990) Acta Chem. Scand. 50, 672-678.
Reymond, J-L., et al. (1995) J. Org. Chem., 60, 6970-6979.
Teraishi. K., et al. (1994) J. Mol. Graphics 12, 282-285.
Flanagan, M. E., et al. (1996) J. Am. Chem. Soc. 6078-6079.

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