Catalytic antibodies and a method of producing same

Details Catalytic antibodies and a method of producing same Catalytic antibodies and a method of producing same

1997-03-26

2000-03-28

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Catalytic antibody

C12N 900

Patent

active

060430699

ABSTRACT:
The present invention is directed generally to catalytic antibodies and, more particularly, to a novel method of producing same. The method of the present invention is predicated in part on the exploitation of the products of catalysis to induce B cell mitogenesis. In a preferred embodiment, a growth factor having an ability to induce B cell mitogenesis is linked to a target antigen to which catalytic antibodies are sought. B cell mitogenesis is then dependent on the catalytic cleavage of the antigen portion of the growth factor by catalytic antibodies on the surface of B cells. The method of the present invention is useful for generating catalytic antibodies for both therapeutic and diagnostic purposes.

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Janda, K.D., et al. (1991) Tetrahedron 47 (14/15), 2503-2506.

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