Catalytic antibodies

Details Catalytic antibodies Catalytic antibodies

2007-04-17

2007-04-17

Patterson, Jr., Charles L. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Catalytic antibody

Reexamination Certificate

active

08447924

ABSTRACT:
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the formation of a complex between the antibody and the reactant. The complexed reactant is converted to the product which is then released from the complex. The monoclonal antibody may employ a cofactor and may be directed to a known substrate of an enzyme. Methods for preparing such monoclonal antibodies are also disclosed.

REFERENCES:
patent: 4888281 (1989-12-01), Schochetman et al.
Kohen et al., “A Steroid Immunoassay Based on Antibody-Enhanced Hydrolysis of a Steroid-Umbelliferone Conjugate,”FEBS Letters, vol. 100, 137-140 (1979).
Raso et al.,Biochemistry, vol. 14, 591-599 (1975).
W.P. Jencks, “Catalysis in Chemistry and Enzymology,” 282 (McGraw Hill, New York 1969).
G.P. Royer, “Enzyme-Like Synthetic Catalysts (Synzymes),”Advance in Catalysis, 29, 197-227 (1980).
J.B. Summers, Jr., “Catalytic Principles of Enzyme Chemistry: Antibody Models and Stereoelectronic Control,” Harvard Univ. Ph.D. Thesis, 22-101 (1983) (UMI Dissertation Inf. Service (1984)).
Enxyme Nomenclature, pp. 274, 278 and 279 (1979).
Sacks et al.,J. Experimental Med., vol. 155, 1108-1119 (1982).
Slobin, L.I., “Preparation and Some Properties of Antibodies with Specificity Towards p-Nitrophenyl Esters,”Biochemistry, vol. 5, 2836-2844 (1966).
Raso et al., “The Antibody-Enzyme Analogy, Characterization of Antibodies Phosphopyridoxyltyrosine Derivatives,”Biochemistry, vol. 14, 584-591 (1975).
Burd et al., “Specific Protein-Binding Reactions, Monitored by Enzymatic Hydrolysis of Ligands-Fluorescent Dye Conjugates,”Analytical Biochemistry, vol. 77, 56-57 (1977).
Kohen et al., “Nonradioisotopic Homogenous Steroid Immunoassays,”J. Steroid Biochemistry, vol. 11, 161-167 (1979).
Kohen et al., “Antibody-Enhanced Hydrolysis of Steroid Esters,”Biochimica et Biophysica Acta, vol. 629, 328-337 (1980).
Kohen et al., “Monoclonal Immunoglobulin in G Augments Hydrolysis of an Ester of the Homologous Hapten,”FEBS Letters, vol. 111, 427-431 (1980).
Kwan et al.,Genetic Engineering, vol. 2, 31-46 (1980).
Frankelton et al.,J. Biol. Chem., vol. 255, 5286-5290 (1980).
Roberts, R.J.,Methods in Enzymology, vol. 68, 27-31 (1979).
White et al.,Principles of Biochem., pp. 200, 201, 217-221, 573, 575 and 585 (1968).
David et al.,Clin. Chem., vol. 27, 1580-1585 (1981).
Melchers et al.,Biochem. Biophys. Res. Comm., vol. 49(3), 570-575 (1970).
Pollack et al.,Science, vol. 234, 1570-1573 (1986).
Tramontano et al.,Science, vol. 234, 1566-1570 (1986).
Research News,Science, vol. 234, 1497-1498 (1986).
Erhan and Greller,Nature, vol. 251, p. 353 (1974).

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