Catalytic and reactive polypeptides and methods for their prepar

Details Catalytic and reactive polypeptides and methods for their prepar Catalytic and reactive polypeptides and methods for their prepar

1992-12-10

1994-05-24

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Catalytic antibody

5303889, 5303898, C12N 900

Patent

active

053148177

ABSTRACT:
Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the binding site, where the active functionality is capable of catalyzing or chemically participating in the chemical reaction in such a way that the reaction rate is enhanced. Methods for preparing the catalytic peptides include chemical synthesis, site-directed mutagenesis of antibody and enzyme genes, covalent attachment of the functionalities through particular amino acid side chains, and the like.
This invention was made with Government support under Grant Contract No. AI-24695, awarded by the Department of health and Human Services, and under Grant Contract No. N 00014-87-K-0256, awarded by the Office of Naval Research. The Government has certain rights in this invention.

REFERENCES:
Krafft, G. A., et al. (1989) Ann. Reports in Medicinal Chem. 25, 299-308.

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