Catalysts for production of .beta.-hydroxy carbonyl compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing

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556 13, 556 19, 556 35, 556 54, 556 55, 556113, 556115, 556116, 556139, 556146, 556148, 556150, 534 16, 564170, 564182, 564201, 568 55, 568496, 568308, 568414, 560 60, C07F 728, C07F 108

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055999638

ABSTRACT:
The invention relates to catalysts for the synthesis of .beta.-hydroxy carbonyl compounds, and in particular to enantioselective catalysts.

REFERENCES:
Smr cina, M., et al., "Synthesis of Enantiomerically Pure Binaphthyl Derivatives. Mechanism of the Enantioselective, Oxidative Coupling of Naphthols and Designing a Catalytic Cycle", J. Org. Chem., 58:4534-4538 (1993).
Sasai, H., et al., "Catalytic Asymmetric Nitroaldol Reactions. A New Practical Method for the Preparation of the Optically Active Lanthanum Complex", Tetrahedron Letters, 34(5):851-854 (1993).
Kobayashi, S., et al., "Catalytifc Asymmetric Aldol Reaction of the Silyl Enol Ether of Acetic Acid Thioester with Aldehydes Using Chiral Tin(II) Lewis Acid", Tetrahedron: Asymmetry, 2(7):635-638 (1991).
Parmee, E. R., et al., "New Catalysts for the Asymmetric Aldol Reaction: Chiral Boranes Prepared from .alpha.,.alpha.-Disubstituted Glycine Arenesulfonamides", J. Am. Chem. Soc., 113:9365-9366 (1991).
Furuta, K., et al., "Chiral (Acyloxy) borane Catalyzed Asymmetric Aldol Type Reaction of Ketene Silyl Acetals with Aldehydes", SYNLETT, :439 (1991).
Kiyooka, S., et al., "The Catalytic Asymmetric Aldol Reaction of Silyl Ketene Acetals with Aldehydes in the Presence of a Chiral Borane Complex. Nitroethane as a Highly Effective Solvent for Catalytic Conditions.sup.1 ", Tetrahedron Letters, 33(34): 4927-4930 (1992).
Parmee, E. R., et al., "The Catalytic Asymmetric Aldol Reaction of Aldehydes with Unsubstituted and Monosubstituted Silyl Ketene Acetals: Formation of Anti-.beta.-Hydroxy-.alpha.-Methyl Esters", Tetrahedron Letters, 33(13):1729-1732 (1992).
Hayashi, M., et al., "Enantioselective Trimethylsilycyanation of Some Aldehydes Catalyzed by Chiral Schiff Base-Titanium Alkoxide Complexes",J. Org. Chem., 58:1515-1522 (1993).
Nitta, H., et al., "Peptide-Titanium Complex as Catalyst for Asymmetric Addition of Hydrogen Cyanide to Aldehyde", J. Am. Chem. Soc., 114:7969-7975 (1992).
Mikami, K., et al., "Asymmetric Catalytic Aldol-type Reaction with Ketene Silyl Acetals: Possible Intervention of the Silatropic Ene Pathway", J. Am. Chem., Soc., 116:4077-4078 (1993).
Kobayashi, S., et al., "Catalytic Asymmetric Aldol-type Reaction Using a Chiral Tin(II) Lewis Acid #", Tetrahedron, 49(9):1761-1772 (1993).

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